PMID: 9551682Apr 29, 1998Paper

Histopathological evaluation of liver fibrosis: quantitative image analysis vs semi-quantitative scores. Comparison with serum markers

Journal of Hepatology
C PilettePaul Calès

Abstract

Liver fibrosis is mainly evaluated by qualitative histological examination. Although histological semi-quantitative scores and quantitative determination with image analysis are now possible, these methods have not been fully validated and compared. Therefore, we evaluated these two methods prospectively in 243 patients with chronic liver disease. The semi-quantitative fibrosis score was evaluated by two independent pathologists, using the Knodell fibrosis score and a 6-grade score derived from the Metavir score; the area of fibrosis was measured by image analysis. The serum levels of hyaluronate, N-terminal peptide of procollagen III, laminin, transforming growth factor-beta1, alpha2-macroglobulin, apolipoprotein A1, PGA score and prothrombin index were measured. There was a good correlation between the semi-quantitative fibrosis score and the area of fibrosis (r=0.84, p<10(-4)). Using multiple regression analysis, the semi-quantitative score was predicted by the 8 serum markers with R2=0.69 (R2=0.59 for hyaluronate at the 1st step) while the area of fibrosis was predicted with R2=0.79 (R2=0.76 for hyaluronate at the 1st step), and the Knodell fibrosis score was predicted with R2=0.65 (R2=0.31 for hyaluronate at the 1st step)....Continue Reading

References

Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P R GibsonF J Dudley
Jun 1, 1991·Clinical Biochemistry·M Plebani, A Burlina
Mar 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Tinè, L Pagliaro
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A NybergL Lööf
Dec 1, 1971·The American Journal of Digestive Diseases·R D SolowayW H Summerskill
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Nov 1, 1994·Digestive Diseases and Sciences·S NaveauJ C Chaput
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Aug 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ChevallierJ A Grimaud
Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N ManabeJ A Grimaud
Dec 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A ParésJ Rodés
Nov 14, 1997·Gastroenterology·F ObertiP Calès

❮ Previous
Next ❯

Citations

Apr 13, 2011·Hepatology International·Laurent Castera
Jun 19, 2013·World Journal of Pediatrics : WJP·Ahmed F AbdallaMohammed Ezz El Regal
Jan 8, 2004·Journal of Hepatology·Valeer J Desmet
Dec 4, 2003·Journal of Hepatology·Thomas KörnerAxel M Gressner
Dec 2, 1999·Journal of Hepatology·C PiletteP Calès
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Don C Rockey
Sep 1, 1999·European Journal of Clinical Investigation·T OgataS Aoyagi
Jun 27, 2002·Journal of Gastroenterology and Hepatology·Kristin AnselmiChandrashekhar R Gandhi
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frédéric MoalPaul Calès
Dec 17, 2003·Journal of Gastroenterology and Hepatology·Gamal M DahabOsama A Sharaf El-Din
Jul 19, 2008·Journal of Gastroenterology and Hepatology·Yong-Peng ChenJin-Lin Hou
Jan 5, 2011·Journal of Gastroenterology and Hepatology·Hyun Jung LeeHo Sang Ryu
Aug 19, 2011·BMC Gastroenterology·Ancha BaranovaZobair M Younossi
Dec 26, 2008·World Journal of Gastroenterology : WJG·Nicola DioguardiCarlo Russo
Jan 7, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jérémy SandriniMarie-Christine Rousselet
Apr 13, 2007·Digestive Diseases and Sciences·Christophe AubéPaul Calès
Jul 17, 2008·Digestive Diseases and Sciences·Hee-Seung LeeSoon-Sun Hong
Oct 1, 2011·Clinical Journal of Gastroenterology·Hiroyasu Morikawa, Norifumi Kawada
Jan 12, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Don C Rockey
May 13, 2008·Gastroenterology·Diarmuid S Manning, Nezam H Afdhal
Nov 30, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Alex Yui HuiJoseph Jao-Yiu Sung
Nov 25, 2003·Alcoholism, Clinical and Experimental Research·Charles S LieberUNKNOWN Veterans Affairs Cooperative Study 391 Group
Jan 5, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J FontanaUNKNOWN HALT-C Trial Group
Dec 14, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Amy L LazzariniSchuyler O Sanderson
Dec 14, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Marc A FriedenbergFrank K Friedenberg
Oct 13, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Ismail I MatalkaToqa M Manasrah
Nov 2, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·Y MaorP Halfon
Apr 22, 2008·Alcoholism, Clinical and Experimental Research·Charles S LieberUNKNOWN Veterans Affairs Cooperative Study 391 Group
Mar 17, 2012·Phytotherapy Research : PTR·Hai-Long ZhaoOk Hee Chai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.