Histopathological features in a case of peters' anomaly with acquired corneal staphyloma

Case Reports in Ophthalmological Medicine
Kumi ShiraiShizuya Saika

Abstract

We report a case of corneal staphyloma histologically diagnosed as caused by Peters' anomaly. A 62-year-old male had a protruding opaque vascularized cornea that began to bulge from six months ago in the right eye. Since his right eye was blind and he wanted us to remove the eyeball for cosmetic improvement, we enucleated the affected eye. The enucleated tissue was fixed in formalin and embedded in paraffin for histological examination. Hematoxylin and eosin staining showed that the cornea lacked the posterior part of the corneal stroma and Descemet's membrane in the central region and the entire corneal endothelium. The corneal epithelium was keratinized. Collagen type I was strongly positive in peripheral cornea and weakly in protruding stroma. The cells labeled by antibodies against αSMA were scattered in the entire corneal stroma. As judged by the histological findings, the eye with the central corneal staphyloma was diagnosed as Peters' anomaly.

References

Mar 1, 1988·The British Veterinary Journal·H J West
Sep 23, 1988·JAMA : the Journal of the American Medical Association
Jan 1, 1984·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·C M Dickinson, R V Abadi
Apr 1, 1983·American Journal of Ophthalmology·D J SchanzlinM Pickford
Sep 1, 1995·Archives of Ophthalmology·P B MullaneyG W Heinz
Mar 31, 1998·Cornea·Gerald W Zaidman, K Juechter

Citations

May 8, 2013·Ophthalmology and Eye Diseases·Robert W Sault, Jeffrey Sheridan

Methods Mentioned

BETA
SMA

Related Concepts

Collagen
Cornea
Corneal Stroma
Corneal Endothelium
Eye
Hematoxylin
Corneal Staphyloma
Dorsal
Right Eye
Histology Procedure

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.