PMID: 9179753May 1, 1997Paper

Histopathological features of canine distemper recently observed in Japan

Journal of Comparative Pathology
M OkitaC Kai

Abstract

Eleven dogs with canine distemper (CD) from the Chubu region of Japan and the Tokyo area were examined. Clinically, respiratory and neurological signs were present in all animals. Histopathologically, all showed characteristic CD lesions of bronchopneumonia and demyelinating encephalitis. However, some differences in gastrointestinal abnormalities were observed. Three out of four dogs from the Chubu region had severe diarrhoea and gastroenteritis, associated with numerous eosinophilic inclusion bodies in the mucosal epithelia. The remaining dog from this area showed vomiting, but not diarrhoea, and also had a number of intraepithelial inclusion bodies in the gastric and intestinal mucosa. In contrast, the seven dogs from the Tokyo area showed neither gastrointestinal symptoms nor intraepithelial inclusions in the stomach or intestine. Immunohistochemical examination for CD virus antigen, however, revealed that these seven dogs had immunoreactive products in the mucosal epithelia, suggesting that the epithelial cells had either a low level of infection with CD virus or were infected with a less cytopathogenic virus. These findings suggest that the dogs in this study were probably affected by two distinct types of CD, in terms of...Continue Reading

References

Nov 1, 1991·The Journal of General Virology·N HirayamaK Yamanouchi
Apr 1, 1980·Japanese Journal of Medical Science & Biology·K Yamanouchi
Dec 1, 1993·The Journal of Veterinary Medical Science·C KaiK Yamanouchi
Aug 1, 1995·The Journal of Veterinary Medical Science·T GemmaC Kai
Jun 1, 1996·The Journal of Veterinary Medical Science·T GemmaT Mikami
Aug 1, 1996·The Journal of Veterinary Medical Science·T GemmaT Mikami

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Citations

Nov 12, 2003·Journal of Virology·Veronika von MesslingRoberto Cattaneo
Nov 21, 2008·Veterinary Immunology and Immunopathology·A BeinekeW Baumgärtner
Sep 9, 2008·Comparative Immunology, Microbiology and Infectious Diseases·Ikuyo TakayamaChieko Kai
Jun 7, 2007·The Journal of Veterinary Medical Science·Takuya KuboAtsuhiko Hasegawa
Sep 24, 2004·Acta Veterinaria Hungarica·Nalan KabakciI S Gurcan
Oct 24, 2007·Journal of Virological Methods·Dong-Jun AnBong-Kyun Park
May 1, 2001·Clinical and Diagnostic Laboratory Immunology·Y IkedaE Takahashi

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