Histopathological Features of Non-Neoplastic Breast Parenchyma Do Not Predict BRCA Mutation Status of Patients with Invasive Breast Cancer

Biomarkers in Cancer
Soley BayraktarAysegul A Sahin

Abstract

Several studies have evaluated histologic features of non-neoplastic breast parenchyma in patients with BRCA1/2 mutations, but the results are conflicting. The limited data suggest a much higher prevalence of high-risk precursor lesions in BRCA carriers. Therefore, we designed this study to compare the clinicopathological characteristics of peritumoral benign breast tissue in patients with and without deleterious BRCA mutations. Women with breast cancer (BC) who were referred for genetic counseling and underwent BRCA genetic testing in 2010 and 2011 were included in the study. Of the six benign histological features analyzed in this study, only stromal fibrosis grade 2/3 was found to be statistically different, with more BRCA noncarriers having stromal fibrosis grade 2/3 than BRCA1/2 carriers (P = 0.04). There is no significant association between mutation risk and the presence of benign histologic features of peritumoral breast parenchyma.

References

Feb 19, 1992·JAMA : the Journal of the American Medical Association·S J LondonG A Colditz
Jan 1, 1990·Epidemiologic Reviews·J L Kelsey, M D Gammon
Aug 10, 1996·Lancet·C C SunS A Narod
Apr 16, 1997·Journal of the National Cancer Institute·J S PankowT A Sellers
Jan 1, 1997·Epidemiologic Reviews·C Goehring, A Morabia
May 20, 1998·Journal of the National Cancer Institute·P O'ConnellD C Allred
Aug 3, 1999·Japanese Journal of Cancer Research : Gann·Y MinamiS Hisamichi
Dec 10, 1999·AJR. American Journal of Roentgenology·E L RosenR C Bentley
Aug 3, 2000·International Journal of Epidemiology·C FriedenreichD Page
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C T BrekelmansUNKNOWN Rotterdam Committee for Medical and Genetic Counseling
Jul 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A FörstiK Hemminki
Jul 21, 2001·The New England Journal of Medicine·H Meijers-HeijboerJ G Klijn
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lauren ScheuerKenneth Offit
Mar 27, 2002·The American Journal of Surgical Pathology·A M ShaabanC S Foster
May 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sunil R LakhaniDouglas F Easton
Jun 6, 2002·Journal of the National Cancer Institute·David M EuhusAdi F Gazdar
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Penelope M WebbGraham A Colditz
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N HoogerbruggeH G Brunner
Mar 4, 2003·Breast Cancer Research and Treatment·Elizabeth B ClausDarryl Carter
Oct 2, 2003·Journal of the National Cancer Institute·William D FoulkesLars A Akslen
Oct 25, 2003·Science·Mary-Claire KingUNKNOWN New York Breast Cancer Study Group
Oct 23, 2004·International Journal of Cancer. Journal International Du Cancer·Helenice GobbiDavid L Page
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil R LakhaniUNKNOWN Breast Cancer Linkage Consortium
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela S LarsonCarol L Rosenberg
Feb 18, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sining ChenGiovanni Parmigiani
May 25, 2006·The Oncologist·Merih Guray, Aysegul A Sahin
Apr 14, 2007·Breast Cancer Research and Treatment·Karin LeunenIgnace Vergote
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria J WorshamSandra R Wolman
Jan 4, 2008·Histopathology·J S Reis-Filho, A N J Tutt
Jan 10, 2008·JAMA : the Journal of the American Medical Association·Colin B BeggJonine L Bernstein
May 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emad A RakhaIan O Ellis
Aug 9, 2008·Nigerian Journal of Medicine : Journal of the National Association of Resident Doctors of Nigeria·A A MayunU D Babayo

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Citations

Apr 19, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hee Eun LeeDaniel W Visscher

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Methods Mentioned

BETA
hormone replacement therapy
biopsy

Software Mentioned

CARRIER
NON
Plus
SAS

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