PMID: 6977353Feb 1, 1982Paper

Histopathological findings in clinical gentamicin ototoxicity

Archives of Otolaryngology
M KeeneJ Farkashidy

Abstract

The temporal bone histopathological findings in a case of gentamicin sulfate-induced hearing loss and vertigo in an anephric patient undergoing hemodialysis are presented. A study of the sensory neuroepithelium of the cristae and maculae disclosed the presence of vacuoles with clubbing of the sensory cells. In the cochlea, loss of the innermost row of outer hair cells in the basal turn was the most prominent feature. These findings are discussed in light of reports of similar morphological changes in laboratory studies of gentamicin ototoxicity.

Citations

Mar 5, 2014·Journal of the Association for Research in Otolaryngology : JARO·C G Le PrellJ M Miller
Jul 1, 1990·British Journal of Clinical Pharmacology·R CheungR J Dobbs
Oct 31, 1987·British Medical Journal·R Duncan, I D Melville
Jan 1, 1989·Cancer Investigation·L GoldenZ Deeb
Sep 12, 2012·The Laryngoscope·Carolyn P Ojano-Dirain, Patrick J Antonelli
Aug 31, 2004·American Journal of Otolaryngology·Takeshi KusunokiMichael M Paparella
Jan 20, 2005·International Journal of Pediatric Otorhinolaryngology·Omer Faruk UnalBülent Gürsel
Dec 19, 2002·Otolaryngologic Clinics of North America·Wayne E Berryhill, Malcolm D Graham
Apr 26, 2012·The Annals of Otology, Rhinology, and Laryngology·Jianfen Luo, Lei Xu
Jan 22, 2002·The Laryngoscope·R HinojosaD R Schramm
Feb 12, 2004·Clinical Pharmacokinetics·Lavern M VercaigneJames M Zacharias
Aug 23, 2006·Acta Oto-laryngologica·Gail IshiyamaRobert W Baloh
Nov 9, 2010·The Journal of Laryngology and Otology·R C DemarcoM A Hyppolito
Jan 1, 1987·Acta Oto-laryngologica. Supplementum·E H Huizing, J C de Groot
Jul 24, 2012·Biochemistry. Biokhimii︠a︡·S S JankauskasD B Zorov
Aug 1, 1988·British Journal of Audiology·J P Griffin
Apr 10, 2019·Archives of Toxicology·Hyejeong HongJason E Farley
Aug 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·W C Leliever
Nov 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C M LuY H Lien

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