Histopathological findings in skeletal muscle used in human dynamic cardiomyoplasty

The Journal of Pathology
P S GutierrezJ A Ramires

Abstract

Patients submitted to dynamic cardiomyoplasty had an initial clinical improvement followed by a decrease in cardiac failure indices. A histopathological study of the skeletal muscle was undertaken to explain this. Latissimus dorsi fragments from 15 patients submitted to dynamic cardiomyoplasty in a 1:1 (heart beat:muscle stimulation) conditioning were analysed by light microscopy. The interval between surgery and obtaining the specimens (13 from necropsies, two from heart transplants) ranged from 37 days to 6 years. Nuclear clumps and internalization, the presence of round fibres, inflammation, and fibrosis were analysed semi-quantitatively; the thickness of muscle fibres and the percentage of tissue fat were measured by image analysis. The quantitative data were also compared, in 12 cases, with gender- and age-matched necropsy controls. The mean thickness of muscle fibres in cases and controls was 27.21+/-5.33 and 40.84+/-9.42 microm, respectively (p=0.001). The percentage of tissue fat in cases and controls was 12.04+/-12.66% and 0.93+/-0.91%, respectively (p=0.008). The duration of grafts correlated positively with the quantity of nuclear clumps (R=0.80, p<0.001) and round fibres (R=0.53, p=0.04), as well as with the percent...Continue Reading

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Citations

Sep 10, 2003·The Annals of Thoracic Surgery·Anderson BenícioSérgio A Oliveira
Dec 4, 2003·Heart & Lung : the Journal of Critical Care·Deniz Süha KüçükaksuOguz Taşdemir
Mar 21, 2002·Artificial Organs·L F Moreira, A A Leirner
Aug 24, 2013·BioMed Research International·Antonio PaoliCarlo Reggiani
Dec 21, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Luiz Alberto BenvenutiMaria de Lourdes Higuchi

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