Histopathological growth patterns as biomarker for adjuvant systemic chemotherapy in patients with resected colorectal liver metastases.

Clinical & Experimental Metastasis
Florian E BuismanCornelis Verhoef

Abstract

Adjuvant systemic chemotherapy (CTx) is widely administered in patients with colorectal liver metastases (CRLM). Histopathological growth patterns (HGPs) are an independent prognostic factor for survival after complete resection. This study evaluates whether HGPs can predict the effectiveness of adjuvant CTx in patients with resected CRLM. Two main types of HGPs can be distinguished; the desmoplastic type and the non-desmoplastic type. Uni- and multivariable analyses for overall survival (OS) and disease-free survival (DFS) were performed, in both patients treated with and without preoperative chemotherapy. A total of 1236 patients from two tertiary centers (Memorial Sloan Kettering Cancer Center, New York, USA; Erasmus MC Cancer Institute, Rotterdam, The Netherlands) were included (period 2000-2016). A total of 656 patients (53.1%) patients received preoperative chemotherapy. Adjuvant CTx was only associated with a superior OS in non-desmoplastic patients that had not been pretreated (adjusted hazard ratio (HR) 0.52, 95% confidence interval (CI) 0.37-0.73, p < 0.001), and not in desmoplastic patients (adjusted HR 1.78, 95% CI 0.75-4.21, p = 0.19). In pretreated patients no significant effect of adjuvant CTx was observed, neith...Continue Reading

References

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Citations

Feb 7, 2021·International Journal of Molecular Sciences·Gemma Garcia-ViciénDavid G Molleví
Aug 17, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Yannick M MeyerJan N M IJzermans
Sep 5, 2021·The Journal of Pathology. Clinical Research·Pieter Mh NieropCornelis Verhoef

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Methods Mentioned

BETA
light microscopy

Software Mentioned

RStudio (
SPSS

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