Histopathological investigation of gingival tissue from patients with rapidly progressive periodontitis

Journal of Periodontology
G HillmannW Geurtsen

Abstract

In this study, fine structural features of the pocket walls in rapidly progressive periodontitis (RPP) and adult periodontitis (AP) in 20 cases were compared using light and transmission electron microscopy. Gingiva was also obtained from a control group of periodontally healthy teeth. Clinical parameters were assessed in both RPP and AP patients and in controls. Bone destruction and attachment loss were more marked in RPP than in AP. Light microscopical observations of inflamed RPP tissue as compared to AP showed gross histological distortions in the pocket walls. Micro-ridges within the epithelium and large intercellular spaces between the epithelial cells were observed in most RPP biopsies. Epithelial cells surrounding the microclefts and adjacent keratinocytes were found to produce interleukin-1beta (IL-1beta). Prevotella intermedia and Porphyromonas gingivalis were identified in the RPP biopsies using immunohistological methods. These microorganisms were localized outside the epithelium and inside intercellular spaces. Furthermore, the effect of inflammation on the distribution of collagen types I, III, IV, V, and VI in the human gingiva was studied after staining them with antibodies to these proteins. In RPP and AP tissu...Continue Reading

References

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Citations

Sep 14, 2002·Infection and Immunity·Margaret A ScraggMichael A Curtis
Dec 20, 2014·International Journal of Endocrinology·Adriana MoneaMonica Monea
Dec 30, 2010·Journal of Periodontology·Juliano Milanezi de AlmeidaValdir Gouveia Garcia
Jul 4, 2014·Biotechnology, Biotechnological Equipment·Ahmet DağMuzaffer Aydın Ketani

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