Histopathological observations of the antivascular effects of physiotherapy ultrasound on a murine neoplasm

Ultrasound in Medicine & Biology
Ralph M BunteAndrew K W Wood

Abstract

This study evaluates the histopathological changes that follow insonation of a neoplasm with physiotherapy ultrasound. In 27 mice (C3HV/HeN strain), a subcutaneous melanoma (K1735(22)) was insonated with continuous physiotherapy ultrasound (1 MHz; spatial-average-temporal-average = 2.3 W cm(-2)). Analyses of contrast enhanced (0.1 mL Optison) power Doppler observations showed that insonation significantly (p < 0.05) increased the avascular area in the neoplasm. The predominant acute effect of insonating the neoplasm was an apparently irreparable dilation of the tumor capillaries with associated intercellular oedema; other immediate effects were haemorrage and increased intercellular fluid. Liquefactive necrosis of neoplastic cells was a delayed effect. There was a high correlation (R2 = 0.91) between the percent area affected on histologic examination and the percent increase in avascularity of the neoplasm in the Doppler study. In conclusion, physiotherapy ultrasound produced histologic changes in the tumor vasculature that were consistent with observations made by contrast enhanced power Doppler ultrasound.

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Citations

Jan 28, 2012·The Journal of the Acoustical Society of America·Benjamin J LevenbackAndrew K W Wood
Dec 18, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Gabriela S SeilerChandra M Sehgal
Apr 13, 2010·Ultrasound in Medicine & Biology·Andrew K W WoodChandra M Sehgal
Aug 28, 2007·Ultrasound in Medicine & Biology·Andrew K W WoodChandra M Sehgal
May 8, 2015·International Journal of Cancer. Journal International Du Cancer·Junfen WangJianping Bin
Mar 3, 2015·Ultrasound in Medicine & Biology·Andrew K W Wood, Chandra M Sehgal
Jan 24, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Stephen J HuntChandra M Sehgal
Jun 20, 2017·Drug Discovery Today·Yi-Ju HoChih-Kuang Yeh
May 30, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Brandon J DeOreChandra M Sehgal
May 28, 2009·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Andrew K W WoodChandra M Sehgal
Aug 1, 2021·Scientific Reports·Mrigendra B KarmacharyaChandra M Sehgal

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