PMID: 3750841Jan 1, 1986Paper

Histopathological predictive factors in Ewing's sarcoma of bone and clinicopathological correlations. A retrospective study of 261 cases

Virchows Archiv. A, Pathological Anatomy and Histopathology
A Llombart-BoschD Sarrazin

Abstract

A retrospective multifactorial analysis on 261 previously untreated patients with Ewing's sarcoma (Es) of bone has been carried out in order to ascertain the prognostic value of several histological variables on survival. Among those cases accepted as Es, 208 (80% of the patients) were considered to be "typical Es", while 40 (15%) displayed a large cell predominance, being subclassified as "atypical large cell Es". Furthermore, 13 patients (5%) possessed tumours of endothelial-like appearance. Eleven cases which displayed a mixed histological configuration were finally included within one of the three previous groups according to their predominant histological pattern. After adjustment for therapeutic regimens and initial location of the tumour, only two histological characteristics remain significant; i.e. the presence of necrosis (p = 0.002) and, to a lesser degree, the presence of filagree "en damier" pattern (p = 0.08), both of which are of poor prognostic value. From this study, it can be assumed that the morphological (and possibly histogenetical) heterogeneity of Es of bone has no prognostic influence on survival.

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Citations

Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P TerrierA Llombart-Bosch
Sep 18, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Daniel E B SwinsonKenneth J O'Byrne
Mar 15, 2005·American Journal of Clinical Pathology·Cheryl M CoffinHolly Zhou
Mar 1, 1989·Ultrastructural Pathology·N G OrdoñezB Mackay
Jan 21, 2012·American Journal of Clinical Pathology·Martin PichlerRichard Zigeuner
Sep 28, 2010·Human Pathology·Marion J PollheimerCord Langner
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A PellinA Llombart-Bosch
Oct 21, 2009·Virchows Archiv : an International Journal of Pathology·Antonio Llombart-BoschPiero Picci
Sep 14, 2001·Clinical Orthopaedics and Related Research·J R CusmariuK Jaffe
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·S DaugaardT Schiødt
Oct 29, 2020·Nature Communications·Patricia P YeeWei Li
Apr 15, 2010·Cancer Research·Ophélie MeynetGhislaine Bernard
May 18, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Patricia P Yee, Wei Li

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