Histopathological prognostic factors predicting para-aortic lymph node metastasis in patients with endometrioid uterine cancer

Gynecologic Oncology
Yuko KarubeToshinobu Tanaka

Abstract

The purpose of this study was to determine histopathological factors for para-aortic lymph node (PALN) metastasis in patients with endometrioid uterine cancer. A total of 355 patients (Stage I, n=269; II, n=24; and III, n=62) (FIGO 2009) underwent primary radical surgery including complete systematic pelvic lymph node (PLN) and PALN dissection in Tohoku Gynecologic Cancer Unit (TGCU) between 1993 and 2004. Logistic regression analysis was used to determine the independent prognostic factors for PALN metastasis. Multivariate analysis revealed that PLN metastasis (p<0.0001) and ovarian metastasis (p=0.0080) related with PALN metastasis. Moreover, among the sites of PLN metastases, obturator lymph node (LN) [risk ratio (RR): 16.9, 95% confidence interval (CI): 4.3-66.4, p<0.0001] and common iliac LN (RR: 7.1, 95% CI: 1.1-44.5, p=0.0375) related with PALN metastases. In detection of PALN metastasis, combination of obturator LN and/or common iliac LN and/or ovarian metastasis (A) revealed 75.9% sensitivity (22/29) and 97.8% negative predictive value (NPV) (304/311). However, by combination of obturator LN metastasis and/or common iliac LN metastasis and/or grade 3 and/or deep myometrial invasion (B), the detection of PALN metastasis...Continue Reading

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Citations

Nov 5, 2013·Gynécologie, obstétrique & fertilité·L RossardL Ouldamer
Sep 8, 2011·Archives of Gynecology and Obstetrics·Taner TuranM Faruk Kose
Jan 22, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z-Q WangL-H Wei
Apr 26, 2011·Gynécologie, obstétrique & fertilité·A-S Bats, P Madelenat
Jun 15, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Taner TuranM Faruk Kose
Aug 28, 2015·The Tohoku Journal of Experimental Medicine·Masahiko KitoYukihiro Terada
Feb 2, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ulas SolmazEmel Ebru Pala
May 10, 2017·Journal of Surgical Oncology·Glauco BaiocchiAlexandre Andre Balieiro Anastacio da Costa
Feb 21, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Sokbom KangKi-Tae Kim
May 20, 2017·International Journal of Clinical Oncology·Mustafa Erkan SariTayfun Gungor

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