Histopathological studies on viral nervous necrosis of sevenband grouper, Epinephelus septemfasciatus Thunberg, at the grow-out stage

Journal of Fish Diseases
S TanakaT Miyazaki

Abstract

Abstract Viral nervous necrosis caused by sevenband grouper nervous necrosis virus (SGNNV) has occurred in grow-out stages (0-3 years old) of sevenband grouper, Epinephelus septemfasciatus, since the 1980s. In the present study, based on histopathological features of the central nervous system (CNS) in naturally diseased fish, pernasal infection experiments using grow-out fish were performed and pernasal infection was established as a putative invasion route of SGNNV. The definite SGNNV-targeted cells were determined by histopathological studies including indirect fluorescent antibody test and electron microscopy. Nerve cells in the olfactory lobe were most extensively necrotized with vacuolation followed by infiltration of microglia and macrophages. Purkinje cells and Golgi cells were extensively infected in the cerebellum. Megalocells and small nerve cell nuclei were also infected in the preoptic area, thalamus, medulla oblongata and spinal cord. Only a few small nerve cells were infected in the olfactory bulb and optic tectum. The retina of some diseased fish displayed vacuolated bipolar cells of the inner nuclear layer and in the ganglion cell layer. These SGNNV-infected nerve cells displayed viroplasmic inclusions containi...Continue Reading

Citations

Dec 14, 2011·Viruses·Mark Crane, Alex Hyatt
Feb 15, 2011·Fish & Shellfish Immunology·Takashi OhtaYuzuru Tozawa
Sep 17, 2009·Journal of Virological Methods·Hai-Dong XuJiang-Yong Wang
May 15, 2018·Transboundary and Emerging Diseases·Y C KimH D Jeong
Feb 14, 2020·Pathogens·Isabel Bandín, Sandra Souto
Jun 5, 2020·Fish & Shellfish Immunology·Pankoj Kumar Das, Irene Salinas

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