PMID: 6636984Jan 1, 1983

Histopathological study of the attrition of challenge cercariae of Schistosoma mansoni in the skin of mice immunized by chronic infection and by use of highly X-irradiated cercariae

Zeitschrift Für Parasitenkunde
S Y HsüS M Johnson


To find direct evidence for the sites of death of newly transformed schistosomula of Schistosoma mansoni in the skin of challenged immunized hosts, a histopathological study of the skin of chronically infected mice and of highly X-irradiated cercaria-immunized mice was made at different post-challenge times. Attrition of infecting organisms in naive mice was used as a control. In general, three main kinds of schistosomular attrition were observed: (1) in the granulocytic exudates in the epidermis, (2) in the granulocytic aggregates in the subcutaneous tissue, and (3) in the granuloma-like foci in the subcutaneous tissue. Schistosomula killed by the epidermal granulocytic exudates and by the subcutaneous granuloma-like foci occurred in all three groups of mice, but the schistosomula killed by the subcutaneous granulocytic aggregates were found only in the highly X-irradiated cercaria-immunized animals. Schistosomula killed by the epidermal granulocytic exudates were encountered occasionally in the challenged naive mice but more frequently in both the challenged chronically infected mice and the challenged highly X-irradiated cercaria-immunized mice. The number of subcutaneous granuloma-like foci was greater in the challenged mic...Continue Reading


May 1, 1974·The American Journal of Tropical Medicine and Hygiene·D A DeanK D Murrell
Jan 1, 1972·Transactions of the Royal Society of Tropical Medicine and Hygiene·K S Warren
Mar 1, 1972·International Journal for Parasitology·J A Clegg, S R Smithers
Mar 1, 1982·Parasite Immunology·D J McLaren, R J Terry
Sep 1, 1980·The American Journal of Tropical Medicine and Hygiene·S R Smithers, K L Miller

Related Concepts

Chronic Disease
Schistosoma mansoni
Katayama Fever
Mouse, Swiss

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