Histopathology and genetic susceptibility in COVID-19 pneumonia

European Journal of Clinical Investigation
Jan von der Thüsen, Menno van der Eerden

Abstract

The clinical features of COVID-19 pneumonia range from a mild illness to patients with a very severe illness with acute hypoxemic respiratory failure requiring ventilation and Intensive Care Unit admission. To provide a brief overview of the existing evidence for such differences in host response and outcome, and generate hypotheses for divergent patterns and avenues for future research, by highlighting similarities and differences in histopathological appearance between COVID-19 and influenza as well as previous coronavirus outbreaks, and by discussing predisposition through genetics and underlying disease. We assessed the available early literature for histopathological patterns of COVID-19 pneumonia and underlying risk factors. The histopathological spectrum of COVID-19 pneumonia includes variable patterns of epithelial damage, vascular complications, fibrosis and inflammation. Risk factors for a fatal disease include older age, respiratory disease, diabetes mellitus, obesity and hypertension. While some risk factors and their potential role in COVID-19 pneumonia are increasingly recognized, little is known about the mechanisms behind episodes of sudden deterioration or the infrequent idiosyncratic clinical demise in otherwi...Continue Reading

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Citations

Aug 12, 2020·European Journal of Clinical Investigation·Jordi Olloquequi
Aug 28, 2020·Expert Review of Molecular Diagnostics·So Yat WuCesar Sze Chuen Wong
Jun 24, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Samuel B PolakJudith van Paassen
Jul 14, 2020·Annals of Hematology·Christopher A LatzAnahita Dua
Sep 15, 2020·Expert Review of Respiratory Medicine·Purva AsraniSukhwinder Singh Sohal
Jan 13, 2021·SN Comprehensive Clinical Medicine·P CapletonNairi Tchrakian
Oct 30, 2020·Eye & Contact Lens·Loretta Szczotka-Flynn
Dec 30, 2020·European Radiology·Lukas EbnerCatherine Beigelman-Aubry
Feb 24, 2021·Expert Review of Molecular Diagnostics·Md Alamgir KabirWaseem Asghar
Jan 6, 2021·Current Opinion in Pulmonary Medicine·Alain C Borczuk
Apr 28, 2021·Expert Review of Respiratory Medicine·Suzana Erico TanniBruno Guedes Baldi
May 22, 2021·European Journal of Medical Research·SeyedAhmad SeyedAlinaghiFabricio Voltarelli
Aug 5, 2021·Experimental and Therapeutic Medicine·Chao LiJun Liu
Sep 22, 2021·Signal Transduction and Targeted Therapy·Hao DengLamei Yuan

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