Histopathology and immunohistologic demonstration of the distribution of Rickettsia typhi in fatal murine typhus

American Journal of Clinical Pathology
D H WalkerJ W Muehlberger

Abstract

An 81-year-old woman had chills, fever, nausea, vomiting, and epigastric pain. On day 3 she had hematuria and was treated with trimethoprim-sulfamethoxazole. On day 5 she had a cough, hypotension, anemia, azotemia, and elevated hepatic enzyme levels. Her condition deteriorated with thrombocytopenia, anuria requiring dialysis, edema, and hypoalbuminemia. Treatment with chloramphenicol and doxycycline was started on day 10. By day 11, she was in hypotensive shock; on day 12 she had seizures and died. Murine typhus was diagnosed by demonstration of antibodies to Rickettsia typhi by indirect immunofluorescence. Necropsy revealed interstitial pneumonia, pulmonary edema, hyaline membranes, alveolar hemorrhages, petechiae and vasculitis in the central nervous system, interstitial myocarditis, multifocal interstitial nephritis and hemorrhages, splenomegaly, portal triaditis, and mucosal hemorrhages in urinary tract. Immunofluorescent R. typhi were demonstrated in the lungs, brain, kidneys, liver, and heart. This unusual death occurred in an elderly patient without rash who was treated too late with antirickettsial drugs.

Citations

Aug 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C G MoronD H Walker
Mar 26, 2003·Vector Borne and Zoonotic Diseases·J A ComerJ E Childs
Jul 16, 2003·Annals of the New York Academy of Sciences·Linda HouhamdiDidier Raoult
Mar 24, 2005·American Journal of Physical Medicine & Rehabilitation·Henry L LewHarriet Zeiner
Aug 19, 2010·Biological Reviews of the Cambridge Philosophical Society·Vicky Merhej, Didier Raoult
May 14, 2014·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Theeraphap ChareonviriyaphapWei Mei Ching
Jul 26, 2014·Emerging Infectious Diseases·Thomas W van der VaartAbraham Goorhuis
Jun 18, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Bernabeu-WittelJ Pachón
Jan 1, 1990·Annals of the New York Academy of Sciences·D H Walker
Apr 16, 2002·Journal of Child Neurology·Emmanouil GalanakisStelios Sbyrakis
Aug 20, 2004·Journal of Bacteriology·Michael P McLeodGeorge M Weinstock
Jul 11, 2006·Pediatric Cardiology·H Rogier van DoornDasja Pajkrt
Apr 27, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E Botelho-Nevers, D Raoult
Oct 24, 2009·BMC Infectious Diseases·Ji-In KangJoonhan Lee
Mar 23, 2017·Emerging Infectious Diseases·Kristy O MurrayTom Sidwa
May 14, 2017·The American Journal of Tropical Medicine and Hygiene·Emily G PieracciChristopher D Paddock
Feb 15, 2019·The American Journal of Tropical Medicine and Hygiene·Evgeny RogozinMiriam Weinberger
Feb 27, 2001·The Pediatric Infectious Disease Journal·R K Brantley
May 5, 1998·Journal of Internal Medicine·F G Van Der KleijW D Reitsma
Apr 16, 2004·Clinical Microbiology Reviews·Douglas A DrevetsRonald A Greenfield
Jan 4, 2008·Vector Borne and Zoonotic Diseases·Gul MadisonGary P Wormser
Jul 12, 2013·Internal Medicine Journal·P A WilsonS Graves
Mar 4, 2020·Tropical Medicine and Infectious Disease·Gregory M Anstead
Nov 28, 2007·Annual Review of Pathology·Gustavo Valbuena, David H Walker
Jun 25, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K NilssonC Påhlson
Dec 5, 2017·Journal of Pediatric Hematology/oncology·Jade WulffMona D Shah
Dec 1, 1992·International Journal of Dermatology·A S Boyd, K H Neldner
Aug 15, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·Achilleas GikasYannis Tselentis
Aug 23, 2019·The American Journal of Tropical Medicine and Hygiene·Teresa A ChuengChristopher L Dayton
Dec 3, 2010·Journal of Clinical Microbiology·Marco H SchulzeAugust Stich
Jan 16, 2004·Scandinavian Journal of Infectious Diseases·Tatiana VanderYuval Herishanu
Feb 13, 2021·Research and Reports in Tropical Medicine·Maria A Caravedo MartinezLucas S Blanton
May 1, 1996·Clinics in Dermatology·J D Baxter
Jul 1, 1996·Clinical Microbiology Reviews·G L Woods, D H Walker
Nov 16, 2007·Journal of Clinical Microbiology·Dong-Min KimSung-Chul Lim
Sep 2, 2021·Journal of Cardiology Cases·Dana ToyDavid M Shavelle

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