PMID: 6539787Apr 1, 1984Paper

Histopathology and pathogenesis of mouse mastitis induced with Staphylococcus aureus mutants

Journal of Comparative Pathology
I Haraldsson, P Jonsson

Abstract

Mammary glands of mice were inoculated with a well-defined strain of Staphylococcus aureus or with derived mutants lacking alpha-haemolysin, coagulase or protein A, in order to evaluate the pathogenicity of these factors. Alpha-haemolysin-negative and coagulase-negative mutants showed less virulence than the wild-type strain. Various protein A-negative mutants gave contradictory results. The lesions ranged from consistently non-reactive necrosis of the entire mammary gland to a limited inflammatory reaction. The necroses, especially when affecting the whole mammary gland, were mostly associated with vascular lesions. Because the necroses were non-reactive, the vascular lesions were considered to be primary, but they could not be linked exclusively with the effect of alpha-haemolysin and a multifactorial aetiology seemed most probable. After inoculation with coagulase-lacking bacteria the development of parenchymal lesions was delayed, hypothetically because of increased phagocytic activity. The investigation indicated that protein A could have influenced the pathogenesis of the lesions, since all but one of the mutants lacking protein A showed low virulence, whereas a high protein A-producing, haemolysin-negative mutant was as ...Continue Reading

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Citations

Oct 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Cooray, P Jonsson
Mar 22, 2005·Microbes and Infection·Eric Brouillette, François Malouin
Oct 1, 1993·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·L F CalvinhoK Dodd
Apr 12, 2006·The Veterinary Quarterly·S Notebaert, E Meyer
Jul 15, 1989·FEMS Microbiology Letters·B Grinde
Jun 1, 1994·Infection and Immunity·M C CalleganR J O'Callaghan
Apr 23, 1987·Biochimica Et Biophysica Acta·M WatanabeT Yasuda

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