Histopathology, hormone products, and clinicopathological profile of endocrine tumors of the upper small intestine: A study of 44 cases

Endocrine Pathology
C CapellaE Solcia

Abstract

Forty-two duodenal and 3 upper jejunum tumors from 44 patients were investigated. All tumors were tested immunohistochemically for gastroenteropancreatic hormones and general endocrine cell markers. Twenty-eight of the 45 tumors (62%) proved to be gastrin cell tumors, with (12 cases) or without (16 cases) associated Zollinger-Ellison syndrome. Zollinger-Ellison syndrome was part of type 1 multiple endocrine neoplasia syndrome in 3 cases. Twenty-three of the 28 gastrin cell tumors (82%) were from proximal duodenum, 2 were from the second part of the duodenum, and 3 were from the upper jejunum. Seven cases were somatostatin cell tumors, 6 of which were from the ampullary region; 5 cases were associated with biliary tract disease and 2 with associated cutaneous neurofibromatosis. Four ganglioneuromatous paragangliomas, from the ampullary region or nearby duodenum, showed somatostatin cells, coupled with pancreatic polypeptide cells in 2 cases. Two serotonin-producing argentaffin carcinoids were also identified. In addition to the main cell type, 30 tumors showed one or more, usually minor, cell populations producing somatostatin, serotonin, cholecystokinin, pancreatic polypeptide, insulin, neurotensin, or the alpha chain of human ...Continue Reading

References

Jan 1, 1975·International Review of Cytology·E SolciaR Buffa
Nov 9, 1978·Cell and Tissue Research·L I Larsson, L M Jørgensen
Feb 1, 1978·The Journal of Clinical Endocrinology and Metabolism·C BordiL Orci
Jul 1, 1979·Gut·K SjölundF Sundler
Mar 15, 1990·The New England Journal of Medicine·M Pipeleers-MarichalP U Heitz
Oct 1, 1985·Pathology, Research and Practice·H MärtenssonS Falkmer
May 1, 1986·The American Journal of Surgical Pathology·Y DayalH J Wolfe
Feb 1, 1989·Pathology, Research and Practice·M LundqvistE Wilander
Oct 1, 1989·The American Journal of Surgical Pathology·A P BurkeE B Helwig
Jan 1, 1985·American Journal of Surgery·B E Stabile, E Passaro
Nov 1, 1986·American Journal of Clinical Pathology·B W ScheithauerJ A Carney
Aug 1, 1987·American Journal of Clinical Pathology·C BordiA Peracchia
Feb 1, 1971·American Journal of Surgery·R F WeichertT Drapanas
Aug 1, 1973·Archives of Surgery·J W HofmannS D Wilson
Oct 1, 1983·The American Journal of Surgical Pathology·Y DayalH J Wolfe
Feb 1, 1984·Journal of Clinical Pathology·D F GriffithsG T Williams
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger

❮ Previous
Next ❯

Citations

Aug 9, 2007·Virchows Archiv : an International Journal of Pathology·Günter KlöppelPaul Komminoth
Sep 25, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Martin AnlaufGünter Klöppel
Apr 28, 2005·Journal of Gastroenterology and Hepatology·Mark HartelMarkus W Büchler
Jun 12, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R García-CarboneroUNKNOWN Spanish Society of Medical Oncology
Apr 5, 2014·Endocrine Pathology·Enrico Solcia, Alessandro Vanoli
Oct 26, 2011·Endocrine-related Cancer·Günter Klöppel
Dec 10, 2015·Virchows Archiv : an International Journal of Pathology·M Johannes RosentraegerGünter Klöppel
Oct 31, 2002·Gastroenterology·Gerhard E FeurleEberhard Weihe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.