Histopathology in a murine model of anthrax.

International Journal of Experimental Pathology
Scott DuongJames E Kirby

Abstract

Systemic anthrax infection is usually fatal even with optimal medical care. Further insights into anthrax pathogenesis are therefore urgently needed to develop more effective therapies. Animal models that reproduce human disease will facilitate this research. Here, we describe the detailed histopathology of systemic anthrax infection in A/J mice infected with Bacillus anthracis Sterne, a strain with reduced virulence for humans. Subcutaneous infection leads to systemic disease with multiple pathologies including oedema, haemorrhage, secondary pneumonia and lymphocytolysis. These pathologies bear marked similarity to primary pathologies observed during human disease. Therefore, this simple, small animal model will allow researchers to study the major pathologies observed in humans, while permitting experimentation in more widely available Biosafety Level 2 facilities.

References

Sep 1, 1978·Human Pathology·S C SuffinA F Kaufmann
Mar 1, 1986·Infection and Immunity·S L WelkosP H Gibbs
Jan 1, 1988·Microbial Pathogenesis·S L Welkos, A M Friedlander
Jan 1, 1985·Infection and Immunity·J O'BrienS Leppla
Jun 25, 1971·Science·G B Van Ness
Aug 1, 1971·The Australian & New Zealand Journal of Obstetrics & Gynaecology·W R Jones
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F A AbramovaD H Walker
May 23, 1998·Science·N S DuesberyG F Vande Woude
Sep 9, 1999·The New England Journal of Medicine·T C DixonP C Hanna
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·L M GrinbergJ H Smith
Dec 19, 2001·Emerging Infectious Diseases·J A JerniganUNKNOWN Anthrax Bioterrorism Investigation Team
Jun 11, 2002·Biochemical and Biophysical Research Communications·Serguei G PopovKen Alibek
Oct 18, 2002·Antimicrobial Agents and Chemotherapy·Thomas B ElliottGregory B Knudson
Oct 25, 2002·Emerging Infectious Diseases·Daniel B JerniganUNKNOWN National Anthrax Epidemiologic Investigation Team
Jul 24, 2003·The American Journal of Pathology·Jeannette GuarnerUNKNOWN Inhalational Anthrax Pathology Working Group
Aug 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Daphne VasconcelosJohn Carney
Dec 23, 2003·Infection and Immunity·James E Kirby
Jan 22, 2004·FEMS Immunology and Medical Microbiology·Vladimir A KarginovKen Alibek
Feb 7, 2004·Cellular Microbiology·Serguei G PopovKen Alibek
Mar 24, 2004·Current Opinion in Microbiology·Mahtab Moayeri, Stephen H Leppla
Apr 29, 2004·JAMA : the Journal of the American Medical Association·Dori B ReissmanBradley A Perkins
Feb 9, 2005·The Journal of Experimental Medicine·Silvia Rossi PaccaniCosima T Baldari
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean-Nicolas TournierPierre L Goossens
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hui FangDavid M Frucht
Oct 28, 2005·The American Journal of Pathology·Aaron M FirovedStephen H Leppla

❮ Previous
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Citations

Nov 3, 2010·Infection and Immunity·Amy JenkinsSusan Welkos
Jul 5, 2013·PloS One·Tao XieDavid M Frucht
Feb 20, 2008·PLoS Pathogens·Shalaka SamantAlexander A Neyfakh
Nov 22, 2008·PLoS Pathogens·Adam C WilsonMarta Perego
Jul 31, 2007·Future Microbiology·Karla D Passalacqua, Nicholas H Bergman
Aug 12, 2009·Molecular Aspects of Medicine·Pierre L Goossens
Dec 19, 2013·Journal of Immunotoxicology·Berrin Zuhal Altunkaynak, Elvan Ozbek
Jun 7, 2011·The American Journal of Pathology·Fabien DumetzPierre Louis Goossens
Jul 27, 2010·Veterinary Pathology·N A Twenhafel
Oct 7, 2015·Infection and Immunity·Chinh T Q NguyenAnthony W Maresso
Oct 30, 2018·The Journal of Veterinary Medical Science·Gorkem EkebasMitat Sahin
Jan 28, 2010·Journal of Medicinal Chemistry·Dimitrios G Bouzianas
Jun 25, 2015·Microbiology Spectrum·Susan WelkosChristopher Cote

❮ Previous
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