Histopathology in giardiasis: a correlation with diarrhoea

Australian and New Zealand Journal of Medicine
V M DuncombeR L Crouch


There is controversy both in regard to the severity of small bowel mucosal damage attributable to giardiasis and to the causal relationship of these changes to the associated diarrhoea. In this series of 17 consecutive patients with giardiasis, small bowel histology and diarrhoea were independently assessed and compared. Disaccharidase assays were performed in 16 of these patients and a repeat biopsy obtained in seven cases. On histological examination the villous architecture varied from normal to sub-total villous atrophy. When these changes were compared with the severity of diarrhoea, a direct correlation was obtained, the more severe symptoms being associated with the more severe villous changes. Repeat biopsy after treatment demonstrated improvement in the histology which correlated with improvement in diarrhoea. Lactase activity was low in all patients with moderate or severe diarrhoea as well as in some patients with mild diarrhoea, two of whom had normal histology. This series demonstrates the occurrence of a spectrum of mucosal changes in giardiasis and supports the concept that these changes mediate the diarrhoea associated with this gut parasite.


Apr 16, 1977·Lancet·K Buschard, J Rygaard
May 1, 1977·Gut·S G WrightD S Ridley
Nov 1, 1975·American Journal of Diseases of Children·J A Burke
Oct 3, 1970·Lancet·G CarpentierE Eggermont
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jun 27, 1970·The Medical Journal of Australia·T D BolinA E Davis
Jan 1, 1971·The American Journal of Clinical Nutrition·L L Brandborg
Jan 1, 1968·Analytical Biochemistry·A Dahlqvist
Feb 1, 1982·Australian and New Zealand Journal of Medicine·T D BolinV M Duncombe
May 1, 1964·The American Journal of Digestive Diseases·J R DA SILVAN DEFIGUIEREDO
Aug 19, 1967·British Medical Journal·S ShusterJ Marks
Jun 1, 1939·Archives of Disease in Childhood·P V Véghelyi


Jan 1, 1995·Parasitology Research·C W Daniels, M Belosevic
Jul 1, 1993·Gastroenterology·A M CevallosM J Farthing
Jun 26, 1999·Alimentary Pharmacology & Therapeutics·C J Vesy, W L Peterson
Jan 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·M J Farthing
Jan 9, 2001·Clinical Microbiology Reviews·T B Gardner, D R Hill
Oct 30, 2007·The Journal of Infection·Kurt HanevikNina Langeland
Jun 19, 2004·Pathology·Adrian G CumminsDavid Gillis
Jul 26, 2014·Expert Review of Anti-infective Therapy·Angel A EscobedoMaydel Alfonso
Sep 1, 1995·Scandinavian Journal of Gastroenterology·G Oberhuber, M Stolte
Dec 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J Farthing
Oct 1, 1991·Annals of Tropical Medicine and Parasitology·C K NainV K Vinayak
Mar 12, 2015·World Journal of Gastroenterology : WJG·Kamran RostamiVincenzo Villanacci
Dec 1, 1987·Infection and Immunity·D R Hill, R D Pearson
Oct 1, 1990·Infection and Immunity·D R Hill, R Pohl
Dec 1, 1990·Parasitology Today·A BuretM E Olson

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.