Histopathology of 460 liver allografts removed at retransplantation: A shift in disease patterns over 27 years

Clinical Transplantation
Lara Neves SouzaAlberto Quaglia

Abstract

Approximately 10%-19% of liver transplant recipients develop irreversible graft failure requiring retransplantation. We reviewed the histology of failed grafts removed at retransplantation in our center over 27 years. Two hundred and seventy-six adults and 118 children underwent retransplantation from 1987 to 2014, receiving 321 and 139 liver grafts, respectively. We analyzed graft histology, recipient demographics, indications and time interval to retransplantation. We divided retransplantation in 3 eras: A (1987-1994), B (1995-2001), and C (2002-2014). A total of 3298 adult and 938 pediatric primary liver transplants were conducted in our center, and 8.4% of adults and 12.6% of children experienced retransplantation. Considering the changes throughout the eras, the proportion of chronic rejection declined, while that of unexplained chronic fibrosing hepatitis increased steadily, representing the main reason for retransplantation conducted >10 years after primary transplant in children, and second in adults in the most recent era. This chronic hepatitis of the graft might correspond to a slowly evolving form of rejection, possibly with a humoral component, associated with progressive graft fibrosis and eventually failure. We o...Continue Reading

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Citations

Jul 16, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Anna MrzljakBranislav Kocman
Nov 11, 2020·Journal of Clinical Medicine·Kerstin HerzerFrank Tacke
Aug 27, 2021·Journal of Hepatology·Julien VionnetAlberto Sánchez-Fueyo
Aug 30, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Emily A SaundersRichard Taubert

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