PMID: 8992608Mar 1, 1996Paper

Histopathology of acetaminophen-induced liver changes: role of interleukin 1 alpha and tumor necrosis factor alpha

Toxicologic Pathology
M E BlazkaM I Luster

Abstract

Administration of 500 mg/kg acetaminophen (APAP) to female B6C3F1 mice resulted in well-documented pathophysiological changes in the liver manifested as increased serum concentration of liver enzymes (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and serum sorbitol dehydrogenase), centrilobular congestion, and hepatocellular degeneration and necrosis. The role of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL-1 alpha), on the hepatotoxicity of APAP was examined at 4, 8, 12, and 24 hr following APAP administration. Neutralization of TNF-alpha or IL-1 alpha with specific antibodies partially prevented the hepatotoxic effects of APAP at the 4- and 8-hr time points. In addition, prior administration of anti-TNF-alpha antibodies shortened the recovery time following APAP treatment. While IL-1 receptor antagonist (IL-1ra) had only a modest protective effect against APAP-induced liver damage, as determined by serum enzyme release, IL-1ra had no effect on the degree of hepatic congestion or necrosis at any of the time points examined. On the other hand, administration of antibodies against IL-1ra exacerbated APAP-induced liver toxicity. These resul...Continue Reading

References

Jan 1, 1990·Annual Review of Biochemistry·K I AraiT Yokota
Aug 2, 1990·Nature·T A Springer
Jan 1, 1991·Advances in Experimental Medicine and Biology·D L Laskin
Sep 11, 1990·European Journal of Biochemistry·K Decker
Jun 7, 1990·The New England Journal of Medicine·T van der PollJ W ten Cate
Jun 15, 1990·Annals of Internal Medicine·G L BirdR S Williams
May 20, 1989·Lancet·K J TraceyA Cerami
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C J McClain, D A Cohen
Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
Feb 15, 1985·Biochemical and Biophysical Research Communications·R J GersonJ L Farber
Jun 1, 1981·European Journal of Clinical Investigation·H E PoulsenH Vilstrup
Apr 1, 1995·Toxicology and Applied Pharmacology·F KayamaM I Luster
Jul 1, 1995·Toxicology and Applied Pharmacology·M E BlazkaM I Luster

❮ Previous
Next ❯

Citations

Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F BoessU A Boelsterli
Aug 10, 2010·European Journal of Clinical Pharmacology·Hugh G LavertyB Kevin Park
Aug 7, 2002·Alcohol·Craig J McClainShirish Barve
Nov 30, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michael Fountoulakis, Laura Suter
Jun 26, 2012·Acta Pharmacologica Sinica·Chun-yan HeJian Zhao
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hidenari NagaiNeil Kaplowitz
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·B Kevin ParkDominic P Williams
Apr 6, 2006·The AAPS Journal·Michael P Holt, Cynthia Ju
Jan 1, 2009·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Adejuwon Adewale Adeneye
Mar 19, 2013·Immunopharmacology and Immunotoxicology·Irmak FerahElif Cadirci
Jan 13, 2012·Drug Metabolism Reviews·Cynthia Ju, Timothy Reilly
Apr 4, 2000·The Journal of Cell Biology·C CaulinR G Oshima
Jul 25, 2006·Expert Opinion on Drug Metabolism & Toxicology·Zhang-Xu Liu, Neil Kaplowitz
Apr 4, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toshihiko Ikeda
Aug 24, 2010·Peptides·Masoumeh Golestan JahromiAli Zare-Mehrjardi
Dec 24, 2015·Gastroenterology Research and Practice·Murat PolatOmer Yilmaz
Jun 20, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Francis F TukovPatricia E Ganey
Aug 25, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Farida HussanFaizah Othman
Jun 3, 2015·Bulletin of Experimental Biology and Medicine·M Sh KhubutiyaYu A Zhgutov
Jul 25, 2006·Toxicology·Dominic P Williams
Jul 10, 2010·Toxicologic Pathology·Brenda FaiolaJohn M Cullen
Nov 7, 2013·Toxicology and Industrial Health·Nuriye Ezgi BekturGonul Unver
Jan 14, 2017·The American Journal of Chinese Medicine·Chia-Chih LiaoFu-Chao Liu
Apr 5, 2017·International Immunopharmacology·Jianping ZhangLi Chu
Feb 26, 2016·Biochimica Et Biophysica Acta·Michaël MaesMathieu Vinken
Nov 4, 2004·Chemico-biological Interactions·Patricia E GaneyRobert A Roth
Aug 29, 2007·Clinics in Liver Disease·Basuki K Gunawan, Neil Kaplowitz
Apr 7, 2000·Clinical Pediatrics·G L KearnsG S Wasserman
Oct 15, 2003·Journal of Leukocyte Biology·Yuko IshidaNaofumi Mukaida
Nov 1, 2017·Antioxidants & Redox Signaling·Patricia RadaÁngela M Valverde
Jun 16, 2017·Gene Regulation and Systems Biology·Lisl Km ShodaBrett A Howell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
F BoessU A Boelsterli
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Yuko IshidaNaofumi Mukaida
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Mohammed BourdiLance R Pohl
© 2022 Meta ULC. All rights reserved