Histopathology of cardiac xenograft rejection in the pig-to-baboon model

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Martin J GoddardJ Wallwork

Abstract

The use of pig organs transgenic for human decay accelerating factor (hDAF) has largely overcome the problems of hyperacute rejection. With improved immunosuppressive protocols, life supporting grafts are showing greater survival times bringing the possibility of clinical xenotransplantation closer. Examination of the histopathology of the rejection process provides insight into the underlying mechanism and may suggest ways in which new immunosuppressive strategies should be directed. 44 baboons (Papio anubis) underwent heart transplants of which 39 were from transgenic donors. The transplanted organs were examined histologically and stained for evidence of immunoglobulin and complement deposition as well as cellular infiltrates. In the transgenic animals survival times were 2 to 99 days (mean 23.5) and the heterotopic group and 1 to 39 days (mean 11.7) in the orthotopic group. There were 3 cases of hyperacute rejection between the 2 groups. Rejected organs showed areas of old and recent myocardial infarction associated with vascular thrombosis. There was widespread deposition within vessels of immunoglobulins IgM and IgG together with complement fractions C3 and C5b to 9 in those organs that were rejected. The amount of comple...Continue Reading

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Citations

Jun 29, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Joel G R WeaverAndrew D Badley
May 28, 2005·Transplantation Proceedings·M C Y ChanR E Morris
Sep 1, 2015·International Journal of Surgery·Muhammad M MohiuddinChristopher G A McGregor
Oct 9, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Davide RicciChristopher G A McGregor
Jul 24, 2007·Thrombosis Research·Baojun ZhangYong Zhao
Aug 12, 2004·Xenotransplantation·Johannes M SchirmerChristopher G A McGregor
Feb 8, 2005·Xenotransplantation·Leo H Buhler, David K C Cooper
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Jun 11, 2003·Xenotransplantation·Henk-Jan SchuurmanTuan Lam
Sep 11, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L G BrockM A Rees
Feb 11, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mario StalderRandall E Morris
May 12, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kiyoshi Ogata, Jeffrey L Platt
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Nov 4, 2016·Clinical Microbiology Reviews·Jianming QiuNeal S Young

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