Histopathology of oligofructose-induced acute laminitis in heifers

Journal of Dairy Science
M B ThoefnerS S Nielsen

Abstract

Histopathology of the dermo-epidermal junction in the lamellar region of front claws was examined in 6 dairy heifers given an alimentary oligofructose overload and compared with sections from a control group of 6 heifers. Four of the 6 heifers administered oligofructose developed clinical signs of acute laminitis before they were euthanized. Postmortem samples from front claws were processed for histology. Eleven histopathologic characteristics were selected from the existing literature and used in a blinded evaluation of sections. In total, 104 front claw samples, including 8 samples from 2 cows having spontaneously occurring acute laminitis, were evaluated histologically using hematoxylin and eosin as well as periodic acid-Schiff staining. The major morphological features associated with oligofructose-induced acute clinical laminitis were stretching of lamellae, dermal edema, hemorrhage, changes in basal cell morphology, presence of white blood cells in dermis, and signs of basement membrane detachment. Changes at the lamellar junction of claw tissue affected by oligofructose-induced clinical laminitis resembled tissue from the 2 cows suffering from spontaneous acute clinical laminitis, and generally were consistent with exis...Continue Reading

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Citations

Feb 4, 2014·Journal of Wildlife Diseases·Sushan Han, Kristin G Mansfield
Jun 19, 2015·Journal of the American Veterinary Medical Association·Daniel U ThomsonBhupinder Bawa
Nov 21, 2017·Journal of Dairy Science·A J HeinrichsC M Jones
Jan 12, 2010·Journal of Dairy Science·A M DanscherO Wattle
Jan 24, 2009·Journal of Dairy Science·A M DanscherM B Thoefner
Aug 6, 2015·Journal of Veterinary Science·Hedie A BustamanteMarianne P Werner
Mar 20, 2019·Journal of Veterinary Pharmacology and Therapeutics·Simon Comerma-SteffensenHector Zerpa
Oct 17, 2014·Physical Biology·Cyril Rauch, Mohammed Cherkaoui-Rbati
Aug 9, 2020·Frontiers in Veterinary Science·Jiafeng DingHongbin Wang
Nov 19, 2020·Animals : an Open Access Journal From MDPI·Carolina ManosalvaRafael Agustín Burgos
Jan 5, 2021·Frontiers in Veterinary Science·Shuaichen LiNa Zhang

Related Concepts

Oligofructose
Basement Membrane
Bos indicus
Cattle Diseases
Organic Pigments
Eosine Yellowish-(YS), Potassium, Sodium Salt
Epidermis
Fluorochromes
Foot Diseases
Haematoxylon

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