Histopathology-validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo-progression in glioblastoma.

Cancer
Hamed AkbariChristos Davatzikos

Abstract

Imaging of glioblastoma patients after maximal safe resection and chemoradiation commonly demonstrates new enhancements that raise concerns about tumor progression. However, in 30% to 50% of patients, these enhancements primarily represent the effects of treatment, or pseudo-progression (PsP). We hypothesize that quantitative machine learning analysis of clinically acquired multiparametric magnetic resonance imaging (mpMRI) can identify subvisual imaging characteristics to provide robust, noninvasive imaging signatures that can distinguish true progression (TP) from PsP. We evaluated independent discovery (n = 40) and replication (n = 23) cohorts of glioblastoma patients who underwent second resection due to progressive radiographic changes suspicious for recurrence. Deep learning and conventional feature extraction methods were used to extract quantitative characteristics from the mpMRI scans. Multivariate analysis of these features revealed radiophenotypic signatures distinguishing among TP, PsP, and mixed response that compared with similar categories blindly defined by board-certified neuropathologists. Additionally, interinstitutional validation was performed on 20 new patients. Patients who demonstrate TP on neuropatholog...Continue Reading

References

Jul 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D R MacdonaldJ G Cairncross
Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·M H Lev, F Hochberg
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Jun 5, 2003·Nature Medicine·Donald M McDonald, Peter L Choyke
Feb 11, 2004·Magnetic Resonance Imaging Clinics of North America·Daniel P Barboriak
Dec 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J Hicklin, Lee M Ellis
Sep 24, 2005·Academic Radiology·Elizabeth BullittMatthew G Ewend
Jan 21, 2006·Journal of Neuroradiology. Journal De Neuroradiologie·M WintermarkH Yonas
Sep 1, 2006·Journal of Neuro-oncology·Marc C ChamberlainAndrew E Sloan
Jul 24, 2007·Nature Reviews. Neuroscience·Rakesh K JainTracy T Batchelor
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Apr 30, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Craig J GalbánBrian D Ross
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
May 25, 2012·The British Journal of Radiology·G ThompsonA Jackson
Mar 15, 2013·Frontiers in Neuroscience·José M SoaresNuno Sousa
Feb 21, 2014·The New England Journal of Medicine·Mark R GilbertMinesh P Mehta
Jul 7, 2014·Current Oncology Reports·Barbara J O'Brien, Rivka R Colen

❮ Previous
Next ❯

Citations

Sep 15, 2020·JCO Clinical Cancer Informatics·Matthew NagyAziz Nazha
May 13, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Martin KocherPhilipp Lohmann
Feb 2, 2021·Neuro-oncology Advances·Niha BeigPallavi Tiwari
Feb 12, 2021·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Bjoern MenzeSpyridon Bakas
Feb 23, 2021·Neuro-oncology Advances·Stephen J BagleyErica L Carpenter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.