Histoplasmosis group disease in bat researchers returning from Cuba

Deutsche medizinische Wochenschrift
K ErkensE C Reisinger

Abstract

Four males (age 25 to 40 years) and one female (age 25) were admitted to our hospital almost simultaneously with symptoms of fever up to 38 degrees C, dry cough, thoracodynia, dyspnoea, myalgia and arthralgia. All patients belonged to a team of eight German bat researchers who had returned from Cuba 10 days before, where they had investigated bats in caves. Another member of the team had only mild histoplasmosis and was followed in our outpatient clinic. Two scientists who wore their breathing masks continuously during their work in the caves did not fall ill. Chest X-rays of all in-patients showed pulmonary infiltrates correlating with the severity of their illness. In all patients specific IgG antibodies against Histoplasma capsulatum-antigen were found in the Western Blot assay, confirming the diagnosis of histoplasmosis. Treatment with oral itraconazole 200 mg b.d was given to four inpatients for 6 weeks, in the fifth patient itraconazole was discontinued because of an increase of liver transaminases. Antimycotic treatment of advancing histoplasmosis seems appropriate also in immunocompetent patients. The high number of patients within this group suggests high numbers of Histoplasma capsulatum in the caves. Wearing breathin...Continue Reading

Citations

Nov 5, 2005·Applied and Environmental Microbiology·Takashi SugitaYoshimasa Uehara
Nov 12, 2003·Emerging Infectious Diseases·Michelle WeinbergRana Hajjeh
Jan 10, 2012·Journal of Travel Medicine·Agathe SénéchalDominique Peyramond
Mar 19, 2008·Journal of Travel Medicine·Boris JülgJohannes R Bogner
Oct 27, 2012·Wiener klinische Wochenschrift·Peter PongratzChristoph Wenisch
Dec 20, 2018·BMC Infectious Diseases·Silvia StaffolaniFrancesco Barchiesi
Nov 10, 2020·Der Pneumologe·Frieder Pfäfflin, Miriam Songa Stegemann

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