Historical aspects of human milk oligosaccharides.

Advances in Nutrition
C Kunz

Abstract

This review focuses on important observations regarding infant health around 1900 when breastfeeding was not considered a matter of importance. The discovery of lactobacilli and bifidobacteria and their relevance for health and disease was an important milestone leading to a decrease in infant mortality in the first year of life. At the same time, pediatricians realized that the fecal composition of breast-fed and bottle-fed infants differed. Observations indicated that this difference is linked to milk composition, particularly due to the milk carbohydrate fraction. Circa 1930, a human milk carbohydrate fraction called gynolactose was identified. This was the starting point of research on human milk oligosaccharides (HMO). In the following years, the first HMO were identified and their functions investigated. Studies after 1950 focused on the identification of various HMO as the bifidus factor in human milk. In the following 30 years, a tremendous amount of research was done with regard to the characterization of individual HMO and HMO patterns in milk. In this short introduction to the history of HMO research, which ends circa 1980, some outstanding scientists in pediatrics and chemistry and their pioneering contributions to ...Continue Reading

References

Jul 10, 1967·Biochemical and Biophysical Research Communications·E F Grollman, V Ginsburg
Jul 1, 1983·Archives of Biochemistry and Biophysics·H EggeH Von Nicolai
Aug 15, 2000·Annual Review of Nutrition·C KunzS Strobel
Jun 26, 2001·Glycoconjugate Journal·A Kobata
Jan 1, 1954·Archives of Biochemistry and Biophysics·P GYORGYC S ROSE
Sep 6, 2011·The British Journal of Nutrition·Silvia RudloffClemens Kunz

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Citations

May 16, 2012·Advances in Nutrition·Clemens KunzSharon M Donovan
Dec 1, 2017·Expert Review of Clinical Immunology·Rachelle PretoriusDebra J Palmer
Aug 9, 2018·Current Developments in Nutrition·Xianli WuPamela R Pehrsson
Jul 1, 2020·Biochemical Society Transactions·Schuyler A Chambers, Steven D Townsend
Jan 21, 2021·ACS Infectious Diseases·Rebecca E MooreSteven D Townsend
Apr 25, 2021·Pediatrics and Neonatology·Yu-Jyun Cheng, Chun-Yan Yeung
Jun 11, 2021·Frontiers in Immunology·Anaïs RousseauxMarie Bodinier

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