Historical background

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
M A Epstein

Abstract

The persisting ancient view of cancer as a contagious disease ended with 19th century scientific investigations which seemed to show it was not. The resulting dogma against an infectious cause for cancer produced great prejudice in the scientific community against the first report of an oncogenic virus by Rous early in the 20th century and, even in the 1950s, against Gross's finding of a murine leukaemia virus and a murine virus causing solid tumours. The Lucké frog renal carcinoma virus was the first cancer-associated herpesvirus. Intriguingly, an environmental factor, ambient temperature, determines virus genome expression in the poikilothermic frog cells. Although an alpha-herpesvirus, Marek's disease virus of chickens shares some aspects of biological behaviour with Epstein-Barr virus (EBV) of man. Very significantly, its lymphomas are the first naturally occurring malignancy to be controlled by an antiviral vaccine, with implications for human virus-associated cancers. The circumstances and climate of opinion in which successive gamma-herpesviruses were discovered are described. The identification of EBV involved two unconventionalities: its finding in cultured Burkitt's lymphoma cells when no human lymphoid cell had ever ...Continue Reading

References

Jul 15, 1975·International Journal of Cancer. Journal International Du Cancer·F Lesnik, L J Ross
Apr 1, 1976·Journal of the National Cancer Institute·M A Epstein
May 15, 1976·International Journal of Cancer. Journal International Du Cancer·P A TrumperB C Giovanella
Jan 1, 1977·Annual Review of Microbiology·M A Epstein, B G Achong
Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·P A TrumperS Finerty
Jan 1, 1979·Archives of Virology·K S Tweedell, M Mizell
Dec 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·M D DanielB F Trum
Jul 29, 1967·Nature·A E Churchill, P M Biggs
Jan 1, 1967·Archiv für die gesamte Virusforschung·M D DanielR D Hunt
Feb 22, 1969·Nature·A E ChurchillR C Chubb
Nov 15, 1970·International Journal of Cancer. Journal International Du Cancer·L V MeléndezM D Williamson
Jul 1, 1971·The Journal of Infectious Diseases·W HenleK Haltia
Dec 20, 1973·The New England Journal of Medicine·R S ChangC F Abildgaard
Feb 14, 1974·The New England Journal of Medicine·R S BarJ F Hewetson
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R F NaegeleR W Darlington
Feb 9, 1972·Nature: New Biology·L V MelendezF G Garcia
Jan 1, 1970·Bibliotheca Haematologica·P M Biggs
Jan 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·G HenleV Diehl
Jan 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·K NazerianB R Burmester
Jan 1, 1980·Archives of Virology·P H LevineD A Stevens
Feb 5, 1994·Lancet·G Niedobitek, L S Young
Feb 12, 1993·Science·N LisitsynM Wigler
Jan 26, 2000·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·P Tiollais, M L Michel
Feb 24, 2001·Current Topics in Microbiology and Immunology·P M Biggs
Jun 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·L GROSS

❮ Previous
Next ❯

Citations

Oct 3, 2008·Cancer Research·Ronald T Javier, Janet S Butel
May 17, 2011·PLoS Pathogens·William N MwangiAdrian L Smith
Sep 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·S C BurgessT F Davison
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andrew C BrownVenugopal Nair
Aug 30, 2011·Autoimmunity Reviews·David H Dreyfus
Sep 5, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Daniel BenharrochJacob Gopas
Aug 4, 2009·Veterinary Immunology and Immunopathology·Hikmet KelesYilmaz Dundar
Jan 12, 2012·British Journal of Haematology·Joe B Harford
Nov 20, 2013·International Journal of Clinical Practice·R A Stein
Jun 23, 2004·Veterinary Immunology and Immunopathology·B J G BaatenT F Davison
Feb 11, 2016·World Journal of Clinical Oncology·Clarke Brian Blackadar
Sep 16, 2008·Archives of Virology·Maryam ChalabiFaranak Rezaie
Sep 19, 2003·The Journal of General Virology·Alexander D BarrowVenugopal K Nair
Aug 13, 2003·Anaesthesia·R Hugh James
Dec 5, 2008·Clinical and Vaccine Immunology : CVI·Changxin WuFred Davison

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.