Historical cohort mortality study of a continuous filament fiberglass manufacturing plant. I. White men

Journal of Occupational and Environmental Medicine
L ChiazzeC Fryar

Abstract

An historical cohort mortality study of a continuous filament fiberglass manufacturing plant was undertaken to determine whether an elevated lung cancer risk would be observed on a cohort basis. A nested case-control study of white male lung cancer deaths was incorporated into the study design. An interview survey to obtain information on sociodemographic factors, including smoking, and an historical environmental reconstruction to identify elements in the plant environment to which workers might be exposed were included in the study design. Respirable glass (Beta) fibers were produced only from 1963 to 1968. The lung cancer odds ratio (OR) among those workers exposed to respirable glass fibers is below unity, as are ORs for exposure to asbestos, refractory ceramic fibers, respirable silica (except for the lowest exposure level), total chrome and arsenic. There is a suggestion of an increase with exposure among smokers only for exposure to formaldehyde, although the OR for the highest level is based on only one case and is not likely to be meaningful. None of these plant exposures suggests an increase in lung cancer risk for this population. Although the lung cancer standardized mortality ratios are slightly elevated, results o...Continue Reading

References

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Citations

Jan 1, 2000·Occupational and Environmental Medicine·D SaliR Saracci
May 14, 2009·Journal of the National Cancer Institute·Laura E Beane FreemanMichael Hauptmann
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Nov 21, 2007·Critical Reviews in Toxicology·David M Bernstein
Jan 13, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C PelucchiC La Vecchia

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