PMID: 8588562Dec 1, 1995Paper

Historical cohort study of spontaneous abortion among fabrication workers in the Semiconductor Health Study: agent-level analysis

American Journal of Industrial Medicine
S H SwanM B Schenker

Abstract

Risk of spontaneous abortion (SAB) was examined in relation to chemical and physical agents in a retrospective study of employees of 14 seminconductor manufacturers: After screening over 6,000 employees, 506 current and 385 former workers were eligible. If a woman had multiple eligible pregnancies, one was selected at random. Telephone interviews provided data on demographics and occupational and other exposures during the first trimester. Two groups of chemicals accounted for the 45% excess risk of SAB among fabrication-room (fab) workers: photoresist and developed solvents (PDS), including glycol ethers, and fluoride compounds used in etching. Women exposed to high levels of both these agents were at greater risk (RR = 3.21, 95% confidence interval [CI] = 1.29-5.96). In fab workers without these exposures, SAB rates were not elevated (adjusted relative risk [RR] = 0.98, 95% CI = 0.55-1.69). An association was seen with workplace stress, which was not limited to women exposed to PDS or fluoride, nor did stress explain the associations between these chemicals and SAB.

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Citations

Dec 1, 1995·American Journal of Industrial Medicine·C J HinesM B Schenker
Jun 14, 2000·Critical Reviews in Toxicology·G Johanson
Dec 7, 2007·International Archives of Occupational and Environmental Health·Aleksandra FucicJoe N Lucas
Mar 27, 2010·American Journal of Industrial Medicine·Eva Y WongHarvey Checkoway
Jul 8, 2014·International Journal of Occupational and Environmental Health·Myoung-Hee KimDomyung Paek
Aug 11, 2018·Journal of Occupational and Environmental Medicine·Oana IanosJeanne Perrin
Mar 27, 2019·Occupational and Environmental Medicine·Luise Moelenberg BegtrupJens Peter Bonde
Jun 11, 1999·American Journal of Industrial Medicine·A SeidlerF W Schwartz
May 30, 2008·International Journal of Occupational and Environmental Health·Ching-Chun LinPau-Chung Chen
May 13, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Donald T WigleDaniel Krewski
Dec 1, 1995·American Journal of Industrial Medicine·B EskenaziM B Schenker
Dec 1, 1995·American Journal of Industrial Medicine·B EskenaziM B Schenker
Dec 1, 1995·American Journal of Industrial Medicine·S J SamuelsM B Schenker
Nov 4, 1998·Journal of Occupational and Environmental Medicine·J C LuoM J Chang
Apr 17, 2007·Epidemiology·Elizabeth A WhelanJanet W Rich-Edwards
May 9, 2012·Journal of Korean Medical Science·Chungsik Yoon
Jun 11, 1999·American Journal of Industrial Medicine·M L Lindbohm
May 10, 2008·Occupational Medicine·Ching-Chun LinPau-Chung Chen
Feb 23, 1999·International Journal of Occupational and Environmental Health·J LaDou, T Rohm
Aug 20, 2019·Annals of Work Exposures and Health·Kyung-Hwa ChoiHo-Jang Kwon
Mar 19, 2020·Occupational and Environmental Medicine·Agathe Croteau
Dec 1, 1995·American Journal of Industrial Medicine·M B SchenkerS H Swan
Nov 10, 2004·Journal of Occupational and Environmental Medicine·Jin Liang ZhuJørn Olsen
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Mar 18, 1999·International Journal of Health Services : Planning, Administration, Evaluation·K Messing
Sep 25, 2019·American Journal of Obstetrics and Gynecology·Chenxi CaiMargie H Davenport

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