Historical Comparison of Overall Survival after Hepatic Resection for Patients With Large and/or Multinodular Hepatocellular Carcinoma

Medicine
Jian-Hong ZhongLe-Qun Li

Abstract

The present study compared the efficacy of hepatic resection (HR) in patients with large hepatocellular carcinoma (HCC) and those with multinodular tumor and examined how that efficacy has changed over time in a large medical center.The intermediate stage of HCC comprises a highly heterogeneous patient population. Moreover, official guidelines have different views on the suitability of HR to treat such patients.A consecutive sample of 927 patients with preserved liver function and large and/or multinodular HCC who were treated by initial HR were divided into 3 groups: those with a single tumor ≥5 cm in diameter (n = 588), 2 to 3 tumors with a maximum diameter >3 cm (n  = 225), or >3 tumors of any diameter (n = 114). Hospital mortality and overall survival (OS) in each group were compared for the years 2000 to 2007 and 2008 to 2013.Patients with >3 tumors showed the highest incidence of hospital mortality of all groups (P < 0.05). Kaplan-Meier survival analysis showed that OS varied across the 3 groups as follows: single tumor > 2 to 3 tumors > 3+ tumors (all P < 0.05). OS at 5 years ranged from 24% to 41% in all 3 groups for the period 2000 to 2007, and from 35% to 46% for the period 2008 to 2013. OS was significantly higher du...Continue Reading

References

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Apr 11, 2014·Scandinavian Journal of Gastroenterology·Jian-Hong ZhongLe-Qun Li
Aug 6, 2014·Nature Reviews. Clinical Oncology·Alejandro FornerJean-Luc Raoul
Sep 10, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jian-Hong ZhongHang Li
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 9, 2015·Nature Reviews. Clinical Oncology·Jian-Hong ZhongLe-Qun Li

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Citations

Jan 14, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liu-Cheng WuJian-Hong Zhong
Oct 27, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jian-Hong Zhong
Nov 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ye-Bin PangLe-Qun Li
Sep 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bao-Hong YuanJian-Hong Zhong
Nov 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lei LiuLe-Qun Li
Apr 27, 2016·Journal of Surgical Oncology·Han-Yue Mo, Jian-Hong Zhong
Aug 28, 2018·Expert Review of Gastroenterology & Hepatology·Ling-Yun ZhaoJian-Hong Zhong
Feb 6, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·X XiangL-Q Li
Feb 15, 2017·BMC Surgery·Ying-Yang LiaoLe-Qun Li
Feb 22, 2017·World Journal of Hepatology·Jian-Hong ZhongLe-Qun Li

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