Historical exposure to persistent organic pollutants and risk of incident hypertension

Environmental Research
Juan P ArrebolaNicolás Olea

Abstract

The aim of this study was to assess the influence of adipose tissue concentrations of a group of persistent organic pollutants (POPs) on the risk of hypertension in an adult cohort of residents of Granada (Southern Spain) over a 10-year follow-up. No chemical was significantly associated with the risk of hypertension in the overall population or when models were stratified by sex or median age. However, we found positive associations between log-transformed POP concentrations and hypertension risk in participants with body mass index (BMI) above the median value of 26.3kg/m(2), which were statistically significant for hexachlorobenzene (HR=1.26, 95% CI=1.03-1.56), β-hexachlorocyclohexane (HR=1.25, 95% CI=1.03-1.51), and polychlorinated biphenyl congeners -138 (HR=1.32, 95% CI=1.04-1.69) and -153 (HR=1.36, 95% CI=1.00-1.84). Inverse associations were observed in the subgroup with BMI≤26.3kg/m(2), but none was statistically significant. More research and a longer follow-up period are warranted to verify these associations and elucidate the role of obesity as a potential effect modifier. Given the elevated worldwide frequency of POP exposure and hypertension, the public health impact of this relationship may be substantial.

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Citations

Aug 25, 2015·Environmental Research·Carlos L CespedesDavid S Seigler
Apr 9, 2016·Environmental Science and Pollution Research International·Su Hyun ParkSun Ha Jee
Nov 16, 2018·Archives of Environmental & Occupational Health·Ana FerroConceição Calhau
Dec 3, 2016·Journal of Environmental Health Science & Engineering·Bita EslamiKazem Naddafi
Mar 8, 2017·Frontiers in Microbiology·Efstratios NikolaivitsEvangelos Topakas
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Jan 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nuno R CoelhoEmília C Monteiro
Aug 28, 2021·Environmental Pollution·Celia Rodríguez-PérezJuan Pedro Arrebola

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