Historical milestones and progress in the research on alcohol septal ablation for hypertrophic obstructive cardiomyopathy

The Canadian Journal of Cardiology
Josef Veselka

Abstract

The first alcohol septal ablation was performed almost 20 years ago in 1994; since then it has become a widely used technique for the treatment of highly symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM). It has been shown that postprocedural basal septal shrinking as a result of myocardial scarring is followed by a decrease in left ventricular (LV) obstruction, regression of LV hypertrophy within the first postprocedural year, improvement of diastolic function, and reduction of the degree of mitral regurgitation. All these changes are accompanied by significant symptom relief. Although there is only limited evidence of postprocedural long-term survival, all the studies presented here are consistent in the low incidence of sudden death and similar prognoses with an age- and sex-matched general population. Conversely, we still have to be aware that a certain knowledge gap exists with regard to postprocedural long-term outcome. Therefore, careful selection of patients for alcohol septal ablation is needed, and all patients should be treated in centres offering all therapeutic options.

References

Mar 1, 1989·Circulation·P BrugadaH J Wellens
Oct 1, 1961·Circulation·J W KIRKLIN, F H ELLIS
Dec 24, 2004·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·C Michael GrossRainer Dietz
Jun 27, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Josef VeselkaPavel Cervinka
May 26, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ali OtoAli Deniz
Dec 12, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Horst J KuhnChristoph Stellbrink
Feb 23, 2010·Journal of the American College of Cardiology·Shikhar AgarwalSamir R Kapadia
Oct 12, 2010·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Horst J Kuhn
Jan 22, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·George LatsiosEberhard Grube
Oct 19, 2012·Circulation·Paul SorajjaRick A Nishimura

Citations

Oct 3, 2012·Interactive Cardiovascular and Thoracic Surgery·Gennady KnyshovBogdan Batsak
Jun 3, 2014·The Canadian Journal of Cardiology·Josef VeselkaDavid Zemánek
Jun 23, 2015·The Canadian Journal of Cardiology·Josef VeselkaPavol Tomašov
Apr 30, 2015·The Canadian Journal of Cardiology·Josef VeselkaMorten K Jensen
May 5, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Silvia Fortunato de CanoJ Eduardo Sousa

Related Concepts

Ethanol
Idiopathic Hypertrophic Subaortic Stenosis
Heart Septum
Solvents
Sclerotherapy
Historical Events,21st Century
Hypertrophic Cardiomyopathy
Sudden Death
Mitral Valve Insufficiency
Obstruction

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