Historical perspective on heart function: the Frank-Starling Law

Biophysics Reviews
Vasco Sequeira, J van der Velden

Abstract

More than a century of research on the Frank-Starling Law has significantly advanced our knowledge about the working heart. The Frank-Starling Law mandates that the heart is able to match cardiac ejection to the dynamic changes occurring in ventricular filling and thereby regulates ventricular contraction and ejection. Significant efforts have been attempted to identify a common fundamental basis for the Frank-Starling heart and, although a unifying idea has still to come forth, there is mounting evidence of a direct relationship between length changes in individual constituents (cardiomyocytes) and their sensitivity to Ca(2+) ions. As the Frank-Starling Law is a vital event for the healthy heart, it is of utmost importance to understand its mechanical basis in order to optimize and organize therapeutic strategies to rescue the failing human heart. The present review is a historic perspective on cardiac muscle function. We "revive" a century of scientific research on the heart's fundamental protein constituents (contractile proteins), to their assemblies in the muscle (the sarcomeres), culminating in a thorough overview of the several synergistically events that compose the Frank-Starling mechanism. It is the authors' personal ...Continue Reading

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Citations

Jun 24, 2017·Biophysics Reviews·Vasco Sequeira, Jolanda van der Velden
Jan 23, 2019·Heart Failure Reviews·Jae Gyun OhKiyotake Ishikawa
Dec 8, 2019·Animals : an Open Access Journal From MDPI·Cuicui CaiHong Chen
Apr 16, 2020·Journal of the American Heart Association·Rahana Y ParbhudayalJolanda van der Velden
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Nov 21, 2020·Progress in Retinal and Eye Research·Murray JohnstoneRuikang K Wang

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