Historical perspective on hormonal therapy of advanced breast cancer

Clinical Therapeutics
Craig Jordan

Abstract

Endocrine therapy is the preferred first-line therapy in patients with nonaggressive, receptor-positive, metastatic breast cancer. Endocrine therapies in these patients are as effective as chemotherapy in terms of survival and tumor response. In addition, hormonal therapies produce fewer and less severe adverse effects than does chemotherapy. Classes of endocrine therapy currently on the market include selective estrogen receptor modulators (SERMs), aromatase inhibitors, and progestins. For several decades, tamoxifen has been considered the gold standard of therapy. However, despite its proven efficacy, a high proportion of patients do not respond. Therefore, a need exists for alternative therapies or for agents to use following tamoxifen failure. This review article highlights the various endocrine options available for patients with advanced breast cancer and discusses new agents on the horizon. Although more studies are needed to determine the optimal sequence of hormonal therapy and the ideal agent within each class, the availability of new and multiple options is encouraging for women with advanced breast cancer.

References

Apr 11, 1992·Lancet·J M Bliss, J R Yarnold
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R W BlameyM Namer
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S DauvoisM G Parker
Jan 1, 1988·Oncology·A U BuzdarG Hortobagyi
Jan 1, 1984·Pharmacology & Therapeutics·B J Furr, V C Jordan
May 17, 1995·Journal of the National Cancer Institute·C K OsborneR I Nicholson
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·C K OsborneA E Wakeling
Jan 1, 1993·Breast Cancer Research and Treatment·L E StenbygaardP Dombernowsky
Aug 26, 1998·The Journal of Steroid Biochemistry and Molecular Biology·A M Brodie, V C Njar
Oct 28, 1998·Journal of the National Cancer Institute·R M O'ReganV C Jordan
Nov 26, 1998·The New England Journal of Medicine·C K Osborne
Jun 13, 2001·Seminars in Oncology·A U Buzdar
Oct 27, 2001·The Breast Journal·G MaugeriF Nardo
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Sacha J HowellAnthony Howell
May 9, 2007·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Junichi Kurebayashi
Jul 6, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Brendan C VisserKim F Rhoads

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Citations

Jul 18, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·James L Mulshine, Fred R Hirsch
Jun 13, 2006·Climacteric : the Journal of the International Menopause Society·J A Gustafsson
Jul 8, 2015·International Journal for Parasitology. Drugs and Drug Resistance·Adriano C CoelhoSilvia R B Uliana
Aug 10, 2007·Expert Opinion on Pharmacotherapy·Lesley-Ann N MillerGerald M Higa
Sep 4, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Akash GuptaRajendra G Mehta
Nov 9, 2016·Archives of Biochemistry and Biophysics·Matthias WolffReinhard Depping
Sep 19, 2009·Expert Opinion on Pharmacotherapy·Gerald M Higa
Mar 12, 2010·Technology in Cancer Research & Treatment·James A EddyNathan D Price
Jul 7, 2007·Physiological Reviews·Nina HeldringJan-Ake Gustafsson
Oct 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lyndsay HarrisUNKNOWN American Society of Clinical Oncology
Dec 28, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel F Hayes, James M Rae
Jul 18, 2014·Cellular and Molecular Life Sciences : CMLS·Zhuan ZhouYong Wan

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