Historical perspectives in gonadotrophin therapy

Human Reproduction Update
Bruno Lunenfeld

Abstract

The 20th century witnessed the steady development of knowledge about the reproductive process in animals and humans. These advances led to the identification of higher centres governing the dynamics of ovarian function and to the discovery of gonadotrophic hormones. As the mechanisms of action of these hormones became increasingly understood, they began to be used in the management of infertility during the early 1930s. Hormone extracts were originally prepared from animal pituitaries and pregnant mare serum, as well as from human pituitaries, placenta and urine, with pregnancies reported following their use in the late 1930s. This review traces the constant quest to reduce risks and improve safety and efficacy of hormone preparations for patients. It describes the complex path and perils leading to the pure hormone preparations that are available today, concluding with an optimistic glimpse towards the future. Small molecules that are orally active and specific are currently being investigated, some with the capacity to bypass many parts of the receptor conformation. Here lies the immediate future of this field, utilizing low-cost, small, defined molecules to stimulate follicle growth, ovulation and corpus luteum formation. Pe...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·F A FaresI Boime
Aug 1, 1990·Australian and New Zealand Journal of Medicine·J I CochiusC P Alderman
Jan 1, 1969·Vitamins and Hormones·B Lunenfeld, A Eshkol
Jan 4, 1997·Lancet·S A BellM Röcken
Mar 1, 1996·Human Reproduction Update·C M Howles
May 1, 1996·Molecular Human Reproduction·W OlijveP M van Wezenbeek
Jul 28, 2001·Human Reproduction·P M BoulouxUNKNOWN FSH-CTP study group
Jun 1, 1953·The Journal of Clinical Endocrinology and Metabolism·L WILKINS
Jun 15, 1954·Experientia·R BORTHH DE WATTEVILLE
Apr 1, 1956·The Journal of Clinical Endocrinology and Metabolism·W O MADDOCKW R ROY
Oct 1, 1958·The Journal of Clinical Endocrinology and Metabolism·A ALBERTE ROSEMBERG
Dec 1, 1958·The Journal of Clinical Endocrinology and Metabolism·C A GEMZELLG TILLINGER
Feb 1, 1961·Endocrinology·S ELLIS
Nov 1, 1959·The Journal of Endocrinology·F BENZW SCHULER
Mar 1, 1962·Fertility and Sterility·C A GEMZELL
Feb 1, 1964·Endocrinology·L E REICHERT, A F PARLOW
Mar 1, 1964·Acta Endocrinologica·P DONINII D ALESSIO
Oct 1, 1964·Metabolism: Clinical and Experimental·J PORATH
Oct 9, 1964·Biochimica Et Biophysica Acta·P ROOS, C A GEMZELL
Oct 3, 2003·British Medical Bulletin·Andrew F Hill, John Collinge
Jan 1, 1949·Acta Orthopaedica Scandinavica·S FRIBERG, C HIRSCH
Jun 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·J T BRADBURYW E BROWN

❮ Previous
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Citations

May 22, 2008·Pituitary·J Lindholm, E Husted Nielsen
Apr 29, 2011·Reviews in Endocrine & Metabolic Disorders·Alfredo Ulloa-AguirreEric Reiter
Aug 2, 2013·Journal of Obstetrics and Gynaecology of India·Sarit Avraham, Daniel S Seidman
Nov 28, 2008·American Journal of Epidemiology·R Calderon-MargalitO Paltiel
Jan 14, 2012·Human Reproduction·Erik LandfeldtOskar Ström
Feb 26, 2009·Human Reproduction Update·UNKNOWN ESHRE Capri Workshop Group
Oct 16, 2009·Reproductive Biology and Endocrinology : RB&E·Sandro C EstevesSilval F C Zabaglia
May 20, 2009·Reproductive Biology and Endocrinology : RB&E·Rita Agostinetto
Sep 25, 2009·Endocrine Reviews·Mark A EdsonMartin M Matzuk
Feb 18, 2010·Biologics : Targets & Therapy·Ahmed Gibreel, Siladitya Bhattacharya
Jul 16, 2013·Archives of Gynecology and Obstetrics·Ruth GomezChristine E Skala
Jan 29, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francisco FábreguesJuan Balasch
Sep 29, 2006·Expert Review of Anticancer Therapy·Jennifer Hirshfeld-Cytron, Helen H Kim
Oct 19, 2014·Expert Opinion on Drug Delivery·Bruno ImthurnManfred Rettenbacher
Nov 27, 2009·Systems Biology in Reproductive Medicine·Feng-Jing LiangYong Wang
Jun 15, 2012·Reproductive Biomedicine Online·John D Biggers
Jun 1, 2005·Reproductive Biomedicine Online·N S Macklon, B C J M Fauser
May 20, 2011·Reproductive Biomedicine Online·Gedis Grudzinskas
Feb 4, 2006·Reproductive Biomedicine Online·C M Howles
Jan 18, 2006·Reproductive Biomedicine Online·Henk J Out
Jun 24, 2006·Reproductive Biomedicine Online·Matts WiklandColin Howles
Feb 2, 2010·Theriogenology·F De RensisM Techakumpu
Nov 26, 2008·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine, Birmingham, Alabama
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·T E Adams, I Boime
Jan 25, 2014·Reproduction in Domestic Animals = Zuchthygiene·F De Rensis, F López-Gatius
Jun 23, 2015·Microscopy Research and Technique·Carlos Eduardo Bezerra MouraPaula De Carvalho Papa
Sep 5, 2013·Molecular and Cellular Endocrinology·Xuliang JiangXiaolin He
Apr 2, 2014·Bioorganic & Medicinal Chemistry Letters·Henry N YuAndreas Goutopoulos
Dec 1, 2010·European Journal of Pharmacology·Pieter VerbostGijs F M Verheijden
Jan 28, 2015·Journal of Human Reproductive Sciences·Madhuri Patil
Jun 9, 2017·Zygote : the Biology of Gametes and Early Embryos·Maxim FilatovMaria Semenova
Feb 25, 2014·The Cochrane Database of Systematic Reviews·Sebastian FranikCindy Farquhar
Jul 10, 2018·Endocrine Reviews·Ross C AndersonRobert P Millar
Jan 26, 2006·Endocrine Reviews·Nick S MacklonBart C J M Fauser
Apr 1, 2019·The World Journal of Men's Health·Alexander J TatemLarry I Lipshultz
Jun 15, 2016·Journal of Veterinary Science·Rafael Herrera AlvarezPaolo Bartolini
May 1, 2012·Expert Review of Endocrinology & Metabolism·Colin M HowlesRoy Homburg
Jul 14, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maria Cristina BudaniGian Mario Tiboni

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