Historical perspectives of prolactin and growth hormone as mammogens, lactogens and galactagogues--agog for the future!

Journal of Mammary Gland Biology and Neoplasia
Josephine F TrottRussell C Hovey

Abstract

Around 80 years ago researchers first established that the pituitary gland regulates mammary gland function as demonstrated by the ability of its extracts to promote both mammogenesis and lactogenesis in animal models. Little did they realize that in fact two hormones, prolactin (PRL) and growth hormone (GH), were contributing to these effects. By the mid 1930s PRL had been purified as a distinct lactogen, while the galactopoietic effect of GH was confirmed after its purification in the 1940s. Interest in these hormones initially centered about their potential for increasing milk production, while in the latter half of the twentieth century it became obvious that these hormones also had the potential to influence mammary cancer development. During the past 50 years large strides have been made into understanding how these hormones signal to, and within, cells of the mammary gland, paralleling rapid developments in the fields of cellular and molecular biology. In compiling this review we have summarized the progress that has been made to date regarding roles for these hormones in the mammary gland, with a goal of ensuring that some of the seminal literature is not diluted or forgotten. In doing so it is clear that there are less...Continue Reading

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Citations

Aug 7, 2009·Journal of Mammary Gland Biology and Neoplasia·Isabel A Forsyth, Margaret C Neville
Aug 19, 2010·Journal of Mammary Gland Biology and Neoplasia·Russell C Hovey, Lucila Aimo
Oct 26, 2010·Endocrine·S Harvey
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Apr 7, 2011·American Journal of Physiology. Endocrinology and Metabolism·Michael C RudolphSteven M Anderson
Oct 11, 2012·Journal of Molecular Endocrinology·J M FlemingP Goldsmith
Aug 31, 2010·Medical Hypotheses·Gabriel Natan PiresSergio Tufik
Jun 16, 2009·Molecular and Cellular Endocrinology·Kristopher C CarverLinda A Schuler
Jul 31, 2012·Wiley Interdisciplinary Reviews. Developmental Biology·Hector Macias, Lindsay Hinck
Apr 22, 2014·Seminars in Cell & Developmental Biology·Robert J Huebner, Andrew J Ewald
Jan 13, 2015·International Journal of Endocrinology·Kerry L Hull, Steve Harvey
Sep 23, 2014·Nature Reviews. Molecular Cell Biology·Eliah R Shamir, Andrew J Ewald
Aug 21, 2014·American Journal of Physiology. Endocrinology and Metabolism·Abby L JohnsonSusan E Waltz
Oct 14, 2019·Cell and Tissue Banking·Seema TripathySaroj Kumar Das
Dec 19, 2019·Journal of Clinical Medicine·Irene SamperiNiki Karavitaki
Sep 4, 2018·Frontiers in Physiology·Tina NapsoAmanda N Sferruzzi-Perri
Jan 14, 2021·Cell and Tissue Research·Ashalyn P WattJulie A Sharp
Jul 3, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity

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