History, applications, and challenges of immune repertoire research

Cell Biology and Toxicology
Xiao Liu, Jinghua Wu

Abstract

The diversity of T and B cells in terms of their receptor sequences is huge in the vertebrate's immune system and provides broad protection against the vast diversity of pathogens. Immune repertoire is defined as the sum of T cell receptors and B cell receptors (also named immunoglobulin) that makes the organism's adaptive immune system. Before the emergence of high-throughput sequencing, the studies on immune repertoire were limited by the underdeveloped methodologies, since it was impossible to capture the whole picture by the low-throughput tools. The massive paralleled sequencing technology suits perfectly the researches on immune repertoire. In this article, we review the history of immune repertoire studies, in terms of technologies and research applications. Particularly, we discuss several aspects of challenges in this field and highlight the efforts to develop potential solutions, in the era of high-throughput sequencing of the immune repertoire.

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Citations

Jul 28, 2019·Immunology·Candace C LiuAaron M Newman
Jun 9, 2020·Clinical and Translational Medicine·Furong YanYiming Zeng
Aug 3, 2019·Bioinformatics·Wei ZhangXiao Liu
Apr 13, 2021·Biochemical Society Transactions·Emma de Jong, Anthony Bosco
May 4, 2021·Frontiers in Molecular Biosciences·Kue Peng Lim, Nur Syafinaz Zainal
Jul 6, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Smita KumariPravir Kumar
Jan 7, 2022·The Journal of Immunology : Official Journal of the American Association of Immunologists·Evan S WalshXinxia Peng

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Methods Mentioned

BETA
electrophoresis
flow cytometry
PCR
random shearing
in silico methods
RNA-seq
flow

Software Mentioned

Illumina Miseq
RTCR
Illumina Hiseq Miseq
IMGT
MiXCR
QUEST
align
HighV
Hiseq
Immune Monitor

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