History of depression, race, and cardiovascular risk in CARDIA

International Journal of Behavioral Medicine
Sarah KnoxMary Whooley

Abstract

Though previous data indicate a positive association between depression and coronary heart disease, the mechanisms mediating these associations remain unclear. These prospective analyses assessed the association between history of Center for Epidemiologic Studies Depression Scale depression and possible mediators of cardiovascular risk at Year 15 of follow-up in African Americans (AA) and Caucasians (C) in the Coronary Artery Risk Development in Young Adults Study. Physiological assessments included plasma levels of low-density-lipoprotein cholestrol (LDL), high-density-lipoprotein cholestrol (HDL), total cholesterol, triglycerides and fasting glucose, diabetes and blood pressure. Behavioral risk factors included alcohol consumption, smoking, physical activity, and body mass index (BMI). AA's showed significant associations between history of depression and diabetes that did not exist in Cs and AA women had significantly more episodes of depression than any other group. However, associations of depression with smoking, BMI, and physical activity were consistent across groups in the expected direction. HDL-cholesterol was positively and LDL-cholesterol inversely associated with depression in Cs, which was unexpected. These data ...Continue Reading

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Citations

Apr 21, 2011·Circulation. Cardiovascular Quality and Outcomes·Tené T LewisSusan A Everson-Rose
Sep 21, 2012·American Journal of Preventive Medicine·Rodney K DishmanSteven N Blair
Jan 24, 2008·Psychosomatics·Ana AzevedoHenrique Barros
Sep 18, 2012·Preventive Medicine·Yeon Soo KimCarol Ewing Garber
Nov 10, 2007·Psychosomatic Medicine·Sarah M ConklinMatthew F Muldoon
Jul 20, 2007·Psychosomatic Medicine·Sherita Hill GoldenConstantine Lyketsos
May 23, 2014·The Journal of Cardiovascular Nursing·Suzanne M Savoy, Sue Penckofer
Aug 11, 2016·International Journal of Adolescent Medicine and Health·Kathleen A PajerSavannah Kalman
Jan 7, 2021·British Journal of Sports Medicine·Rodney K DishmanMatthew Payton Herring

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