History of falls in Parkinson disease is associated with reduced cholinergic activity.

Neurology
N I BohnenR L Albin

Abstract

To investigate the relationships between history of falls and cholinergic vs dopaminergic denervation in patients with Parkinson disease (PD). There is a need to explore nondopaminergic mechanisms of gait control as the majority of motor impairments associated with falls in PD are resistant to dopaminergic treatment. Alterations in cholinergic neurotransmission in PD may be implicated because of evidence that gait control depends on cholinergic system-mediated higher-level cortical and subcortical processing, including pedunculopontine nucleus (PPN) function. In this cross-sectional study, 44 patients with PD (Hoehn & Yahr stages I-III) without dementia and 15 control subjects underwent a clinical assessment and [(11)C]methyl-4-piperidinyl propionate (PMP) acetylcholinesterase (AChE) and [(11)C]dihydrotetrabenazine (DTBZ) vesicular monoamine transporter type 2 (VMAT2) brain PET imaging. Seventeen patients (38.6%) reported a history of falls and 27 patients had no falls. Analysis of covariance of the cortical AChE hydrolysis rates demonstrated reduced cortical AChE in the PD fallers group (-12.3%) followed by the PD nonfallers (-6.6%) compared to control subjects (F = 7.22, p = 0.0004). Thalamic AChE activity was lower only in t...Continue Reading

Citations

Dec 18, 2012·Journal of Neural Transmission·Abraham Lieberman, Narayanan Krishnamurthi
Jun 8, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alfonso FasanoAlfredo Berardelli
Aug 15, 2013·Current Neurology and Neuroscience Reports·Martijn L T M Müller, Nicolaas I Bohnen
Oct 19, 2013·Current Neurology and Neuroscience Reports·Talia HermanJeffrey M Hausdorff
Jan 29, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·A Jon Stoessl
Dec 23, 2011·Parkinsonism & Related Disorders·Nicola Pavese
Feb 8, 2011·Nature Reviews. Neurology·Marie Vidailhet
Feb 24, 2011·Nature Reviews. Neurology·Nicolaas I Bohnen, Roger L Albin
Jun 10, 2011·Brain : a Journal of Neurology·Nicolaas I BohnenRoger L Albin
Sep 11, 2012·Brain : a Journal of Neurology·Lynn RochesterDavid J Burn
Sep 24, 2013·Brain : a Journal of Neurology·Martijn L T M MüllerNicolaas I Bohnen
May 4, 2012·Cold Spring Harbor Perspectives in Medicine·Martin NiethammerDavid Eidelberg
Jul 24, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y H HiorthJ P Larsen
Jul 4, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·David GrabliChantal François
Jul 5, 2011·Neurosurgery·Wesley ThevathasanPeter A Silburn
Oct 23, 2010·Drugs & Aging·Frédéric BlochGilles Kemoun
Apr 18, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Roee HoltzerHelena M Blumen
Jul 7, 2012·Imaging in Medicine·Myria PetrouNicolaas I Bohnen
May 29, 2014·Annals of Biomedical Engineering·Ryan T RoemmichChris J Hass
Nov 12, 2014·Nature Reviews. Neurology·Marios Politis
Jan 23, 2016·Lancet Neurology·Caroline MoreauLuc Defebvre
Aug 13, 2011·The International Journal of Neuroscience·Francesco Raudino, Serena Leva
Jul 5, 2011·Expert Review of Neurotherapeutics·Orit Segev-JacubovskiJeffrey M Hausdorff
Nov 23, 2013·Parkinsonism & Related Disorders·A Jon Stoessl
Dec 20, 2015·Parkinsonism & Related Disorders·Kelvin L ChouNicolaas I Bohnen
Nov 15, 2013·Journal of Neuropathology and Experimental Neurology·Dagmar Hyacintha HeppW D J van de Berg
Jun 26, 2012·Behavioural Brain Research·Carsten HolzmannAndreas Wree
Mar 15, 2012·Neuroscience Letters·Vikas KotagalNicolaas I Bohnen
Oct 22, 2011·Lancet Neurology·A Jon StoesslVesna Sossi
Sep 8, 2011·Progress in Neurobiology·David J Brooks, Nicola Pavese
Jan 5, 2011·Parkinsonism & Related Disorders·Daniel O ClaassenKeith A Josephs
Dec 25, 2015·BMC Neurology·Martina ManciniJohn G Nutt
Jan 12, 2010·Behavioural Brain Research·Nicolaas I Bohnen, Roger L Albin
May 10, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nicolaas I BohnenKirk A Frey
Mar 12, 2016·Reviews in the Neurosciences·Jacob J CrouseAhmed A Moustafa
Nov 29, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Tatsuya KikuchiToshiaki Irie
Jun 11, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Magdalena Eriksson DomellöfLars Forsgren

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

Related Papers

Behavioural Brain Research
N I Bohnen, R L Albin
Movement Disorders : Official Journal of the Movement Disorder Society
Alison J YarnallDavid J Burn
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
N I BohnenK A Frey
© 2022 Meta ULC. All rights reserved