History of miscarriage and increased incidence of fetal aneuploidy in subsequent pregnancy

Obstetrics and Gynecology
Katherine BiancoMary E Norton

Abstract

The purpose of this study was to examine the association between history of spontaneous abortion and aneuploidy in a subsequent pregnancy. This was a retrospective cohort study of women who underwent fetal karyotype analysis with amniocentesis or chorionic villus sampling at a single prenatal diagnosis center. Information on spontaneous abortions, parity, maternal age, ethnicity, type of prenatal diagnosis, and karyotype was assessed. Univariable and multivariable analyses were conducted. A total of 46,939 women were included in our analysis. Women with no prior spontaneous abortions had a 1.39% risk for any aneuploidy. In women with one prior spontaneous abortion, this risk increased to 1.67%; for women with 2 previous spontaneous abortions, the risk increased to 1.84%; and for those women who had had 3 or more prior spontaneous abortions, the risk increased further to 2.18% (P < .007). When controlling for maternal age, parity, ethnicity, and mode of prenatal diagnosis and compared with women with no prior spontaneous abortions, women with one prior spontaneous abortion (adjusted odds ratio [AOR] 1.21, 95% confidence interval [CI] 1.01-1.47) or 3 or more prior spontaneous abortions (AOR 1.51, 95% CI 1.02-2.25) had a statistic...Continue Reading

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Citations

May 7, 2009·Journal of Genetics·Santhosh Girirajan
Aug 5, 2011·Human Reproduction·Vivian RittenbergTarek El-Toukhy
Feb 17, 2007·Clinical Obstetrics and Gynecology·Joe Leigh Simpson
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Feb 2, 2011·Paediatric and Perinatal Epidemiology·A Materna-KirylukUNKNOWN Members of PRCM Working Group
Nov 20, 2009·American Journal of Obstetrics and Gynecology·David KanterIsaac E Stillman
Sep 3, 2009·American Journal of Medical Genetics. Part a·Ana Paula Carneiro BrandalizeLavínia Schüler-Faccini
Feb 6, 2019·Biology of Reproduction·Carmen RubioCarlos Simón
Feb 13, 2020·Reproductive Sciences·Daisy Leon-MartinezKatherine Bianco
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Aug 25, 2018·Molecular Cytogenetics·Xiangyu ZhuYali Hu
Jun 25, 2020·International Journal of Molecular Sciences·Ermanno GrecoPaolo Barillari
Mar 9, 2021·Taiwanese Journal of Obstetrics & Gynecology·Xinyuan LiPing Zhou

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