History of Neural Stem Cell Research and Its Clinical Application

Neurologia Medico-chirurgica
Yasushi Takagi

Abstract

"Once development was ended…in the adult centers, the nerve paths are something fixed and immutable. Everything may die, nothing may be regenerated," wrote Santiago Ramón y Cajal, a Spanish neuroanatomist and Nobel Prize winner and the father of modern neuroscience. This statement was the central dogma in neuroscience for a long time. However, in the 1960s, neural stem cells (NSCs) were discovered. Since then, our knowledge about NSCs has continued to grow. This review focuses on our current knowledge about NSCs and their surrounding microenvironment. In addition, the clinical application of NSCs for the treatment of various central nervous system diseases is also summarized.

References

Jun 1, 1991·Lancet·Y Agid
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S A Goldman, F Nottebohm
Jul 30, 1982·Science·R T BartusA S Lippa
Dec 1, 1994·Hippocampus·R C O'Reilly, J L McClelland
Jan 1, 1997·Molecular and Cellular Neurosciences·T D PalmerF H Gage
Oct 8, 1998·The New England Journal of Medicine·F QureshiA Zaritsky
Oct 8, 1998·The New England Journal of Medicine·A E Lang, A M Lozano
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Jan 6, 1999·Experimental Neurology·S B DunnettA J Morton
Feb 26, 2000·Science·F H Gage
May 18, 2000·Nature Neuroscience·A Björklund, O Lindvall
Dec 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·T B FreemanO Isacson
Jun 2, 2001·The New England Journal of Medicine·L P Rowland, N A Shneider
Aug 7, 2001·Journal of Neuropathology and Experimental Neurology·P Hagell, P Brundin
Dec 4, 2001·Nature Biotechnology·B E ReubinoffT Ben-Hur
Jul 24, 2002·Brain : a Journal of Neurology·M J ThiebenR S J Frackowiak
Aug 6, 2002·Nature Medicine·Andreas ArvidssonOlle Lindvall
Aug 15, 2002·Cell·Hynek WichterleThomas M Jessell
Nov 20, 2002·Journal of Neurochemistry·Kimberly Nixon, Fulton T Crews
Nov 26, 2002·Annals of Neurology·Jack M ParentDonna M Ferriero

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Citations

Feb 15, 2020·Current Stem Cell Research & Therapy·Samira AsgharzadeFatemeh Forouzanfar
Jan 10, 2021·Stem Cell Reviews and Reports·Lacy E LowryJames A Bynum
Jul 28, 2021·Progress in Neurobiology·Nasim Bahram SanganiChris P Reutelingsperger

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Methods Mentioned

BETA
transgenic

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