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History of recurrent mucocutaneous herpes correlates with relatively low interferon production by herpes simplex virus-exposed cultured monocytes

Journal of Medical Virology

May 1, 1988

K Linnavuori

PMID: 2842448

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Abstract

Monocytes separated from blood specimens of healthy voluntary blood donors were infected with herpes simplex virus (HSV) 1 or 2. The amount of interferon produced by the HSV-exposed monocytes was found to be donor-specific and was similar whether tested with HSV 1 or HSV 2. The interfer...read more

Mentioned in this Paper

Interferon Production
Antibodies, Viral
Herpes NOS
Simplexvirus
Human Herpesvirus 2
Human herpesvirus 1
Neonatal Herpes
Human leukocyte interferon
Interferon
Interferons
Paper Details
References
  • References12
  • Citations13
12
  • References12
  • Citations13
12

Feeds With Similar Papers

Herpes Simplex Infections

Herpes simplex virus infections are one of the most common sexually transmitted diseases and are classified as either type 1 (cold sores) or type 2 (genital herpes). Discover the latest research on Herpes Simplex Virus here.

Interferon Signalling

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

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History of recurrent mucocutaneous herpes correlates with relatively low interferon production by herpes simplex virus-exposed cultured monocytes

Journal of Medical Virology

May 1, 1988

K Linnavuori

PMID: 2842448

DOI:

Abstract

Monocytes separated from blood specimens of healthy voluntary blood donors were infected with herpes simplex virus (HSV) 1 or 2. The amount of interferon produced by the HSV-exposed monocytes was found to be donor-specific and was similar whether tested with HSV 1 or HSV 2. The interfer...read more

Mentioned in this Paper

Interferon Production
Antibodies, Viral
Herpes NOS
Simplexvirus
Human Herpesvirus 2
Human herpesvirus 1
Neonatal Herpes
Human leukocyte interferon
Interferon
Interferons

Feeds With Similar Papers

Herpes Simplex Infections

Herpes simplex virus infections are one of the most common sexually transmitted diseases and are classified as either type 1 (cold sores) or type 2 (genital herpes). Discover the latest research on Herpes Simplex Virus here.

Interferon Signalling

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

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Paper Details
References
  • References12
  • Citations13
12
  • References12
  • Citations13
12

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