History of suicide attempt and right superior temporal gyrus volume in youth with treatment-resistant major depressive disorder

Journal of Affective Disorders
Quinn McLellanFrank P MacMaster

Abstract

Growing evidence suggests an endophenotype for suicidality, including brain morphometric features, could provide an improved platform for suicide risk assessment. Reduced right superior temporal gyrus (rSTG) volumes have been implicated in suicidality across psychiatric disorders. Treatment-resistant depression (TRD) has unique neurobiology and adolescents with TRD are at increased suicide risk. Here, we investigated whether reduced rSTG volume was present in adolescents with TRD and history of suicide attempt. 45 adolescents - 14 with history of suicide attempt and TRD, 14 without a suicide attempt history and TRD, and 17 healthy controls - underwent magnetic resonance imaging and reconstructed rSTG volumes were compared. Depressive and anxious symptoms were assessed with Hamilton depression and anxiety rating scales, and differences between attempters and non-attempters were explored. Adolescents with TRD and history of suicide attempt showed reduced rSTG volume compared to healthy controls. Exploratory analyses revealed greater diurnal variation in depressive symptoms in the suicide attempt group compared to non-attempters. Sample size and temporal separation between suicide attempt date and data collection limits interpreta...Continue Reading

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Citations

Aug 21, 2020·The Australian and New Zealand Journal of Psychiatry·Jiaying GongYing Wang
Nov 30, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shengnan WeiFei Wang
Nov 3, 2021·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Bronwyn J OversJanice M Fullerton

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