History of the ductus arteriosus: 1. Anatomy and spontaneous closure

Neonatology
Michael Obladen

Abstract

Ductus arteriosus and foramen ovale were described by Galen without understanding their functions. His beliefs in soul localization and spiritization within the left ventricle established religious pneumatology which became a theological need in the Middle Ages. Pulmonary transit was recognized by Servetus and Colombo after the Reformation around 1550. This prompted Harvey's full understanding of the fetal circulation. Botallo did not describe the ductus arteriosus, but in 1564 redescribed the foramen ovale, making his way into the nomina anatomica by mistake. Most authors of the 19th and 20th century believed ductal patency to be passive, and postnatal closure to be an active process, explained by mechanical theories. After the discovery of prostaglandins by Bergstrom and Vane, Coceani proved that ductal patency is maintained by the relaxant action of prostaglandins.

Citations

Mar 15, 2012·Seminars in Perinatology·Jeff Reese
Dec 18, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Paulo Zielinsky, Stefano Busato
Nov 24, 2018·Congenital Heart Disease·Stacey L CrockettJeff Reese
Feb 6, 2019·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Cristin Conrad, Desi Newberry
Aug 2, 2019·Congenital Heart Disease·Alessia CallegariMartin Christmann
Jul 16, 2020·Journal of Medical Biography·Pamela TozzoFabio Zampieri
Nov 8, 2020·Journal of Anatomy·Fabio ZampieriAlberto Zanatta
May 4, 2021·Frontiers in Pediatrics·Begüm AtasayYogen Singh

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