Histotripsy Ablations in a Porcine Liver Model: Feasibility of Respiratory Motion Compensation by Alteration of the Ablation Zone Prescription Shape.

Cardiovascular and Interventional Radiology
Katherine C LongoTimothy J Ziemlewicz

Abstract

Previous human-scale porcine liver model studies of histotripsy have resulted in ablation zones elongated in the cranial-caudal (CC) dimension due to uninterrupted respiratory motion during the ablation procedure. The purpose of this study is to compensate for elongation of hepatic histotripsy ablation zones in the cranial-caudal (CC) dimension caused by respiratory motion by prescribing ellipsoid-shaped ablations. Six female swine underwent 12 hepatic histotripsy ablations using a prototype clinical histotripsy system under general anesthesia. Each animal received two ablation zones prescribed as either an ellipsoid (2.5 cm (AP) × 2.5 cm (ML) × 1.7 cm (CC), prescribed volume = 5.8 cc) or a sphere (2.5 cm all dimensions, prescribed volume 8.2 cc). Ventilatory tidal volume was held constant at 400 cc for all ablations. Post-procedure MRI was followed by sacrifice and gross and microscopic histology. Ablations on MRI were slightly larger than prescribed in all dimensions. Ellipsoid plan ablations (2.8 × 3.0 × 3.1 cm, volume 13.2 cc, sphericity index 0.987) were closer to prescribed volume than spherical plan ablations (2.9 × 3.1 × 3.7 cm, volume 17.1 cc, sphericity index 0.953). Ellipsoid plan ablations were more spherical than s...Continue Reading

References

Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Cihat Ozhasoglu, Martin J Murphy
Jul 2, 2005·International Journal of Radiation Oncology, Biology, Physics·Laura A DawsonKristy K Brock
Dec 21, 2005·Ultrasound in Medicine & Biology·Jessica E ParsonsJ Brian Fowlkes
Jan 22, 2008·The Journal of Urology·A M LakeW W Roberts
Jul 10, 2010·International Journal of Radiation Oncology, Biology, Physics·Paul J KeallStine Korreman
May 3, 2013·Cardiovascular and Interventional Radiology·Alban DenysPierre Bize
Nov 19, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kenneth PoelsMark De Ridder
Dec 20, 2013·Physics in Medicine and Biology·Eli VlaisavljevichZhen Xu
Sep 10, 2014·International Journal of Radiation Oncology, Biology, Physics·Qianyi XuTamara LaCouture
Mar 11, 2015·International Journal of Radiation Oncology, Biology, Physics·Chiara PaganelliMarco Riboldi
Jul 13, 2016·Ultrasound in Medicine & Biology·Eli VlaisavljevichZhen Xu
Aug 15, 2017·Acta Anaesthesiologica Scandinavica·K GalménJ G Jakobsson
May 28, 2019·Journal of Vascular and Interventional Radiology : JVIR·Emily A KnottTimothy J Ziemlewicz

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Citations

Apr 4, 2021·Diagnostics·Terrence Ch HuiUei Pua

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