PMID: 1206847Jul 1, 1975Paper

Histoxic hypoxia as one of the causes of ventricular fibrillation and decreased myocardial contractility

Kardiologiia
I Ia PevznerM M Eppel'

Abstract

Long-lasting infusions of adrenalin were demonstrated to result in histotoxic hypoxy of the myocardium and its decreased contractility. After a preliminary ligation of several branches of the coronary arteries such situations often caused ventricular fibrillation. The restoration of the myocardial contractility and of the oxydation processes was achieved by the administration of Unithiol, Methionin, Cystein and Succimere. The latter often produce an unusual effect--arrest of ventricular fibrillation and restoration of a normal cardiac rhythm without electric defibrillation. The beneficial effect of these drugs is attributed by the authors to the presence of thiol groups in their structure.

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Patologicheskaia fiziologiia i èksperimental'naia terapiia
O A ShebelevN A Khodorovich
Anesteziologiia i reanimatologiia
N Iu SemigolovskiĭA V Malashenko
© 2022 Meta ULC. All rights reserved