Hitchhiking both ways: effect of two interfering selective sweeps on linked neutral variation.

Genetics
Luis-Miguel ChevinFrédéric Hospital

Abstract

The neutral polymorphism pattern in the vicinity of a selective sweep can be altered by both stochastic and deterministic factors. Here, we focus on the impact of another selective sweep in the region of influence of a first one. We study the signature left on neutral polymorphism by positive selection at two closely linked loci, when both beneficial mutations reach fixation. We show that, depending on the timing of selective sweeps and on their selection coefficients, the two hitchhiking effects can interfere with each other, leading to less reduction in heterozygosity than a single selective sweep of the same magnitude and more importantly to an excess of intermediate-frequency variants relative to neutrality under some parameter values. This pattern can be sustained and potentially alter the detection of positive selection, including by provoking spurious detection of balancing selection. In situations where positive selection is suspected a priori at several closely linked loci, the polymorphism pattern in the region may also be informative about their selective histories.

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Citations

Sep 28, 2010·BMC Evolutionary Biology·Iderval S Sobrinho, Reinaldo A de Brito
Jun 12, 2012·PLoS Genetics·Daniel B Weissman, Nicholas H Barton
Oct 4, 2008·Genetics·Luis-Miguel Chevin, Frédéric Hospital
Jun 21, 2012·Genetics·Graham Coop, Peter Ralph
May 14, 2011·Molecular Ecology Resources·Wolfgang Stephan
Jun 17, 2010·Evolution; International Journal of Organic Evolution·Nicolas Bierne
Jun 10, 2015·Human Genetics·Bryony Leigh JonesDallas M Swallow
Apr 19, 2015·Journal of Translational Medicine·Sara TomeiLotfi Chouchane
Apr 3, 2016·Molecular Ecology·Tetyana NosenkoWolfgang Stephan
Jul 14, 2010·Journal of Mathematical Biology·Kristan A Schneider, Yuseob Kim
Jan 18, 2019·Molecular Ecology·Krystyna Nadachowska-BrzyskaHans Ellegren
Mar 30, 2019·Genetics·José Luis Campos, Brian Charlesworth
Feb 8, 2018·Royal Society Open Science·Katharina B BöndelWolfgang Stephan
Jan 11, 2019·Genetics·Wolfgang Stephan
Jan 25, 2020·G3 : Genes - Genomes - Genetics·Matthew Hartfield, Thomas Bataillon
Feb 25, 2014·Genetics·Lawrence H Uricchio, Ryan D Hernandez
Jan 14, 2021·American Journal of Human Genetics·Aaron J SternRasmus Nielsen
Dec 9, 2020·Entropy·Wolfgang Stephan, Sona John

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