Nov 9, 2007

Hitchhiking effects of recurrent beneficial amino acid substitutions in the Drosophila melanogaster genome

Genome Research
Peter Andolfatto

Abstract

Several recent studies have estimated that a large fraction of amino acid divergence between species of Drosophila was fixed by positive selection, using statistical approaches based on the McDonald-Kreitman test. However, little is known about associated selection coefficients of beneficial amino acid mutations. Recurrent selective sweeps associated with adaptive substitutions should leave a characteristic signature in genome variability data that contains information about the frequency and strength of selection. Here, I document a significant negative correlation between the level and the frequency of synonymous site polymorphism and the rate of protein evolution in highly recombining regions of the X chromosome of D. melanogaster. This pattern is predicted by recurrent adaptive protein evolution and suggests that adaptation is an important determinant of patterns of neutral variation genome-wide. Using a maximum likelihood approach, I estimate the product of the rate and strength of selection under a recurrent genetic hitchhiking model, lambda2N(e)s approximately 3 x 10(-8). Using an approach based on the McDonald-Kreitman test, I estimate that approximately 50% of divergent amino acids were driven to fixation by positive s...Continue Reading

  • References44
  • Citations120
  • References44
  • Citations120

Citations

Mentioned in this Paper

Genetic Drift
Amino Acids, I.V. solution additive
Sample Fixation
Drosophila
Sense Codon
X Chromosome
Genome, Insect
Psathyrella
Drosophila
Genetic Polymorphism

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