Hitting the sweet spot: exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies.

Current Opinion in HIV and AIDS
Kshitij WaghBette T Korber

Abstract

The surface of the HIV-1 Env glycoprotein, the target of neutralizing antibodies, is extensively covered by N-linked glycans that create a glycan shield. Broadly neutralizing antibodies (bNAbs), the primary targets of HIV-1 vaccine design, have to negotiate this glycan shield. Here, we review the barriers and opportunities that the HIV-1 glycan shield presents for vaccine induction of bNAbs. Glycan shields can impact the nature of the antibody response and influence the development of neutralization breadth in HIV-1 infections. The architecture of the glycan shield arising from glycan interactions and dynamics have been modeled, and its fine structure, that is, the site-wise glycan heterogeneity, has been determined for some isolates. Although the extent of glycan shielding is conserved, the precise number, location and processing of glycans, however, is strain-dependent. New insights continue to reveal how such differences can impact bNAb activity and development. Novel approaches have exploited the glycan shield for designing immunogens that bind the germline precursors of bNAbs, a critical roadblock for vaccine-induction of bNAbs. The HIV-1 glycan shield can significantly impact the induction and maturation of bNAbs, and a b...Continue Reading

References

Apr 27, 2007·Nature·Christopher N ScanlanRaymond A Dwek
Dec 23, 2015·Nature Structural & Molecular Biology·Jason GormanPeter D Kwong
Apr 27, 2016·Cell·Guillaume B E Stewart-JonesPeter D Kwong
Sep 13, 2016·Nature Structural & Molecular Biology·Harry B GristickPamela J Bjorkman
Jan 17, 2017·Nature Medicine·Marina CaskeyFlorian Klein
Jan 31, 2017·Immunological Reviews·Leonidas StamatatosAndrew T McGuire
Jan 31, 2017·Immunological Reviews·Bette KorberBeatrice H Hahn
Jan 31, 2017·Immunological Reviews·Mattia BonsignoriBarton F Haynes
Mar 17, 2017·Science Translational Medicine·Mattia BonsignoriBarton F Haynes
Mar 30, 2017·Nature Communications·Liwei CaoJames C Paulson
Apr 20, 2017·Current Opinion in HIV and AIDS·Marie PanceraPeter D Kwong
Apr 27, 2017·Cell Reports·Tongqing ZhouPeter D Kwong
Mar 30, 2018·Annual Review of Biophysics·Max CrispinIan A Wilson
Oct 20, 2018·Nature Immunology·Devin Sok, Dennis R Burton
Jan 11, 2019·Cell Host & Microbe·Christine A BricaultBette Korber
Apr 28, 2019·Journal of Molecular Biology·Gemma E SeabrightMax Crispin
May 31, 2019·Nature·Amelia EscolanoMichel C Nussenzweig
Nov 2, 2019·Science Translational Medicine·Barton F HaynesJohn R Mascola

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Citations

Jun 3, 2021·Viruses·Johnathan D Guest, Brian G Pierce
Jul 18, 2021·Seminars in Immunology·Jeong Hyun Lee, Shane Crotty

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