HIV-1 compartmentalization in diverse leukocyte populations during antiretroviral therapy

Journal of Leukocyte Biology
Simon J PotterN K Saksena

Abstract

CD4+ T lymphocytes are the primary target of human immunodeficiency virus type 1 (HIV-1), but there is increasing evidence that other immune cells in the blood, including CD8+ T lymphocytes and monocytes, are also productively infected. The extent to which these additional cellular reservoirs contribute to ongoing immunodeficiency and viral persistence during therapy remains unclear. In this study, we conducted a detailed investigation of HIV-1 diversity and genetic structure in CD4+ T cells, CD8+ T cells, and monocytes of 13 patients receiving highly active antiretroviral therapy (HAART). Analysis of molecular variance and nonparametric tests performed on HIV-1 envelope sequences provided statistically significant evidence of viral compartmentalization in different leukocyte populations. Signature pattern analysis and predictions of coreceptor use provided no evidence that selection arising from viral tropism was responsible for the genetic structure observed. Analysis of viral genetic variation in different leukocyte populations demonstrated the action of founder effects as well as significant variation in the extent of genetic differentiation between subpopulations among patients. In the absence of evidence for leukocyte-spe...Continue Reading

References

Feb 1, 1992·AIDS Research and Human Retroviruses·P InnocentiJ M Seigneurin
Sep 1, 1992·AIDS Research and Human Retroviruses·B Korber, G Myers
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G PantaleoA S Fauci
Dec 1, 1991·The Journal of Infectious Diseases·C H FoxA S Fauci
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M J McElrathZ A Cohn
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M E HarperF Wong-Staal
Apr 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·R Levins
Nov 21, 1997·Computer Applications in the Biosciences : CABIOS·Z Yang
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·L FlamandR C Gallo
May 16, 1998·The Journal of Experimental Medicine·L P YangG Delespesse
Sep 17, 1998·Journal of Leukocyte Biology·G SemenzatoA De Rossi
May 20, 1999·Molecular Membrane Biology·T L Hoffman, R W Doms
May 26, 1999·The New England Journal of Medicine·L ZhangD D Ho
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·I M Rouzine, J M Coffin
Oct 3, 1999·Molecular Biology and Evolution·J S Rogers, D L Swofford
Mar 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·O LambotteJ F Delfraissy
Mar 10, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·K SahaB Zerhouni
Apr 3, 2001·Nature Medicine·D G BrooksJ A Zack
Jun 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·S D FrostA J Brown

❮ Previous
Next ❯

Citations

Dec 13, 2005·Sexual Health·Megan C SteainNitin K Saksena
May 29, 2010·AIDS Research and Human Retroviruses·Ombretta TurrizianiGuido Antonelli
Jul 29, 2011·Journal of Virology·Adam M SpivakJoel N Blankson
Jan 25, 2008·Virology Journal·Yung Shwen HoNitin K Saksena
Dec 14, 2011·Viruses·Christopher J A Duncan, Quentin J Sattentau
Apr 19, 2005·Expert Opinion on Biological Therapy·L R Meireles-de-Souza, Robin J Shattock
Sep 9, 2015·Journal of Medical Virology·Jun Yong ChoiJune Myung Kim
Mar 24, 2012·Current Opinion in Virology·Nuno Rodrigues FariaPhilippe Lemey
Aug 9, 2006·Evolution; International Journal of Organic Evolution·Daniel ShrinerJames I Mullins
May 25, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Choo Beng ChewNitin K Saksena
Sep 12, 2015·Chemical Research in Toxicology·Danyel G J JennenJos C S Kleinjans
Jan 13, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Barbara A Blacklaws
Nov 23, 2006·Revista Do Instituto De Medicina Tropical De São Paulo·Cynthia Liliane Motta do CantoJosé Eduardo Levi
Aug 12, 2018·International Journal of Environmental Research and Public Health·Andrea AriasVanessa Rivera-Amill
Jul 13, 2019·Frontiers in Immunology·Michelle E WongAnna C Hearps

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved